The Effect Of The Ethanolic Leaf Extract Of Vernonia Amygdalina On Castor Oil Induced Diarrhoea In Wistar Albino Rats

ABSTRACT

File aim of this study is to access the effect of leaf extract of Vernon/a unygcfa/ina (bitter leaf) on castor oil induced diarrhoea in waster albino rats. Thstor oil induced diarrhoea was studied using loperamide (0.006mg/g) as a credence standard in wistar albino rats. The mean number of wet feaces was Intermixed. The result showed that Vernon/a ainygdalina exhibited a dose lependent, significant antidiarrhoeal activity against castor oil induced liarrhoea in wistar albino rats. From the result, the mean weight of faeces for operarnide is 1.10 ± 0.12, for 40mg/bOg is 2.12 ± 0.28, for 20mg/lOOg is 2.45 0.25 and their percentage inhibition are 64.28%, 31.16%, and 20.45% respectively. Hence, the extracts at 40mg/lOOg body weights sibilantly clayed the onset of diarrhoea in 4 hours and reduce the mean weight of faeces to (2.12 ± 0.28) when compared with the negative control group which is (3.08 0.25). the percentage inhibition exhibited by 40mg/lOOg was high at 3 1.16% ihcn compared with positive control group (loperarnide) which was 64.28%. In conclusion, the result of this investigation revealed that 96% ethanol leaf  extract of Vernonia ainygdalina contains pharmacologically active substance(s) anti-diarrhoeal efficacy.