Susceptibility Pattern Of Candida Albicans To Commonly Used Antifungal Drugs In Abia State

ABSTRACT

This study was done to determine the susceptibility pattern of Candida albicans on commonly used antifungal drugs like ketoconazole, Itraconazole, Fluconazole, Terbinafine, Amphotericin B and Gallic acid. The susceptibility pattern of Candida albicans were examined using the disk diffusion method, gallic acid combined with fluconazole has a zone of inhibition of 34.6mm, Gallic acid combined with. amphotericin B has a zone of inhibition of 21.0mm, gallic acid combined with itraconazole has a zone of inhibition of 14.6mm, gallic acid combined with ketoconazole has a zone of inhibition of 35.3mm and gallic acid combined with terbinafine has a zone of inhibition of 25.0mm. Gallic acid alone has a zone of inhibition of 12.00mm, fluconazole alone has a zone of inhibition of 28.3mm, amphoteincin B alone has a zone of inhibition of 9.6mm, itraconazole alone has a zone of inhibition of 14.0mm, ketoconazole alone has a zone of inhibition of 34.3mm and terbinafine alone has a zone of inhibition of 25.0mm the culture media used was Sabourand Dextrose Agar. The result indicates that combined antifungal drugs with gallic acid is more effective and shows a higher zone of inhibiton than single antifungal drugs.