Nephroprotective Potentials Of Methanol Extract Of Dennettiatripetala (Pepper Fruit) Fresh Leaves On Male Albino Rats:- Ndubueze, John-paul E.

ABSTRACT

This study aimed at determining some kidney function indices in albino rats administered methanol leave extract of Dennetiia tripetala. Twenty healthy male albino rats weighing between 180- 240g were divided into four groups of five rats each were used in this study. Group 1 was the control group, group 2 received an oral dose of 100 mg/kg, methanol leave extract of Dennettia tripetala daily, group 3 received an oral dose of 200 mg/kg methanol leave extract of Dennetiia tripetala daily while group 4 received an oral dose of 400 mg/kg ethanol leave extract of Dennettia tripetala daily. After 21 days of administration the rats were sacrificed blood sample were collected through ocular puncture to assay the biochemical parameters. The result of creatinine (mol/L) showed a significant increase (p>0.05) when compared to the control while urea (mol/L) showed significant decrease (p<0.05) when compared to the control. In conclusion the result of this study has shown that administration of methanol leave extract of Dennettia tripetala at dose over lOOmg/kg body weight for a long period oftime may induce toxicity to the kidney which may hamper renal dysfunction.