Lipid Profile And Kidney Function Indices Of Carbon Tetrachloride (Cci4) Induced Male Wistar Albino Rats Treated With Ethanol Extracts Of Alstonia Booneistem Barks.:- Ejimmadu, Charity C

ABSTRACT xi The study was done to ascertain the effect of ethanol extract ofAlstonia boonei stem bark on lipid profile and kidney function indices of carbon tetrachloride (CCI4) induced on male Wistar albino rats. Initially, 18 mice were divided into six groups with 3 mice for each group which were used for phase I and II acute toxicity respectively. However, thirty male Wistar albino rats were added, which was divided into six groups with each group possessing five rats for each. Group 1 was not given CCI4, but served as the normal control. Group 2, 3, 4, 5 and 6 were treated intraperitoneal with 2ml/kg body weight of CC14. Wistar albino rats of group 3 were orally administered a standard drug known as silymarin while group 4, 5 and 6 were given extract of Alstonia boonei stem bark. All procedures were carried out using standard methods. The percentage yield of ethanol extract ofAlstonia boonei stem bark was 23%. Acute toxicity at 5000mg/kg body weight showed no form of adverse effect such as dizziness, drowsiness and fatigue which is an indication of the safety and non-toxicity of the extract. CCL, administration elevated serum urea and creatinine concentrations after induction but were significantly (p<0.05) decreased after treatment with graded ofthe extract. Serum total cholesterol, low density lipoprotein and triacylglycerol (TAG) showed significant (p<0.05) increase in concentration after induction of CC14 and further increase after treatment with graded doses ofthe extract. Also, serum high density lipoprotein decreased in concentration after CCI4 induction but was elevated after treatment with graded doses of the extract. Hence, it can be said that ethanol extract ofAlstonia boonei stem bark is a promising antidote for the treatment of renal injury as well as enhancement in lipid profile composition for the prevention of atherosclerosis, hyperlipidemia and its associated diseases