Extended Spectrum Beta- Lactamase (Esbl) Producing Escherichia. Coli And Klebsiella Pneumonia From Urinary Tract Infection Patients In Federal Medical Center, Umuahia

ABSTRACT

Extended spectrum β- Lactamase (ESBL) producing Enterobacteriaceae have become widespread in hospitals and are increasing in community settings where they cause a variety of infections. 40 clinical isolates from federal medical centre, Umuahia patients was investigated. The isolates were made of 22 Escherichia coli and 18 Klebsiella pneumoniae. Antimicrobial susceptibility was determined by disc diffusion method. ESBL producers were determined by the double disc method using ceftazdime and cefuroxime. Out of the 40 isolates, ESBL producers are made of 15 (68.2%) E. coli and 12 (66.7%) K. pneumonia. ESBL producing isolates were found be in higher proportions from in patients 12 (30%) than out patients. ESBL producing isolates were also found to be more among the female patients 30 (75%) than the male patients 10 (25%). However, nitrofuration and ciprofloxacin was found to have excellent performance against the urinary isolates tested and therefore is recommended for the treatment of infections caused  by Escherichia coli and Klebsiella pneumonia. 

TABLE OF CONTENTS

Certification

Dedication ﾿

Acknowledgements ﾿

Tables of Contents ﾿

List of Tables ﾿

Abstract ﾿

CHAPTER ONE

1.1 ﾿ INTRODUCTION ﾿

1.2 ﾿ Aims and Objectives ﾿

CHAPTER TWO

2.0 ﾿ LITERATURE REVIEW ﾿

CHAPTER THREE

MATERIALS AND METHOD ﾿

CHAPTER FOUR

4.0 ﾿ RESULTS ﾿

CHAPTER FIVE

5.0 ﾿ DISCUSSION AND CONCLUSION ﾿

5.1 ﾿ Discussion ﾿

5.2 ﾿ Summary and Conclusion ﾿

5.3 ﾿ Contribution to Knowledge ﾿

5.4 ﾿ Recommendation ﾿

﾿ References ﾿

Appendix