Evaluation Of Diuretic And Anti-Inflammatory Potential Of Ethanol Extract Of Combretum Platypterum:- Anedu Michael-J

ABSTRACT x The present study was designed to evaluate the diuretic and anti-inflammatory potential on ethanol extract activities ofthe plant Combretumplatypterum. Fourteen animals were used in the diuretic and anti-inflammatory study, and they were divided into VII groups and randomly distributed two animals per group. The results ofthe antioxidant activity ofC. platypterum extract containing 200, 100, 50, 25, and 12.5 mg/ml, all three formulations were evaluated for antioxidants activity by using DPPH, Antilipid.Peroxidation, and Nitric.Oxide models given the results, with the range of 0.00±0.00f to 99.37±0.29a where they were proven to be non-significant making them to be dose dependent. In the diuretic study, the concentration at 1500mg/kg and 3000mg/kg ofthe ethanol extract had the highest significant dose dependent increase in urinary excretion and urinary sodium loss but no effect on urinary potassium loss. Group I (negative control) receiving standard laboratory feed and portable water ad libitum. Group II fruseamide (positive control) receiving feed, water and fruseamide. Group III to VH received the extract ranging from 3000mg/ml to 187.5mg/ml. The results gotten ranged from 0.15±-0.49e to 87.25±70.10a respectively. Egg albumin was used as the inflammatory agent together with a normal saline, and aspirin dissolved in 2ml of water. 0.1ml was administered to each animals paw before measurements were taken every 30 min interval, having the range of2.05±0.10c to 3.45±0.10a. The negative control showed no inhibition. Further results showed that in anti-inflammatory test, egg albumin-induced inflammation model is non-significant for anti-inflammatory activity. The research cited in this review, contribute to justifying the traditional use ofthe genus Combretum for the treatment of various health problem.