Evaluation of biochemical change of commonly used Anti-hypertensive drug (lisinopril) in human subject :- Onyia Chinaza M.

ABSTRACT

Hypertension is the major health problem throughout the world because of its high prevalence and its association with increased risk of cardiovascular diseases. The aim of present study was to evaluate the liver function changes in hypertensive patients receiving lisinopril in umuahia Abia state, Nigeria. The subjects used for this study were thirty-five (35) adult aged between 30 and 60 who were diagnosed positive for hypertension and on Lisinopril treatment and fifteen (15) adult aged between 18 and 24 who were negative for hypertension served as control subjects. All the participants after taking informed consent were subjected to detailed history and blood collected by venipuncture for the study. Students-'t' test was used to find out the significant difference between the two groups. P values less than 0,05 was considered the level of significance. The icsult showed a significant increase (p<0.05) in aspartate aminotransferase activity (AST), urea and bilirubin level in the hypertensive group taking lisinopril when compared will* tnc noimotensivc control group while the results for alanine aminotransferase (ALT), creatinine and alkaline phosphatase (ALP) did not show significant difference (p>0.05) in die hypertensive gioup (lisinopiil) when compared with the normotensive control group. From the results obtained it can bcr concluded that lisinopril, an Antihypertensive drug has an impact on biochemical biomarkers such as AST, Urea and Bilirubin