Assessment Of Alpha Amylase And Pancreatic Lipase Inhibitory Potential Of Hyptis Suaveolens And Mode Of Inhibition:- Lawai Lukman

ABSTRACT

Diabetes, a state of improperly regulated homeostasis of carbohydrate and lipid metabolism is one of the major killers in recent times. Most prevalent form of diabetes is non insulin dependent diabetes mellitus (NIDDM or type II). Rapid hydrolysis of starch mediated pancreatic alpha amylase and lipase followed by glucose uptake at intestine results in sudden rise in blood glucose levels, causing hyperglycemia in type II diabetic patients. The purpose of this present study is to investigate the effect of Hyptis suaveolens on alpha amylase and pancreatic lipase and their mode of inhibition. The results showed that the plant extract (20 mg/mL; 51.8%) was able to inhibit alpha amylase comparable to the standard acarbose at 12.5pg/mL (78) in a competitive manner. Also the plant extract showed a promising pancreatic lipase inhibitory effect with increasing concentrations similar to acarbose in an uncompetitive manner as mode of inhibition. Hyptis suaveolens could be used in the management of diabetic complications.