Anti-Hypertensive Potential Of Ethanol Extract Of Avocado Pear Seed In Male Wistar Rats

ABSTRACT

This study was aimed at determining the anti-hypertensive potential of ethanol extract of Persea americana seed (avocado pear) in male Wistar albino rats. Twenty-four rats were used for this study and they were divided into 6 groups of 4 rats each. Group 1 (normal control), group 2 (hypertensive untreated), group 3 (hypertensive + 10mg/kg b.w of frusemide, a standard anti- hypertensive drug), group 4 (hypertensive + 200mg/kg b. wt of extract), group 5 (hypertensive ± 400mg/kg b. wt of extract) and group 6 (hypertensive + 600 mg/kg b. wt of extract). Except for group 1, which received 100% growers mash, all other groups received 92% growers mash and lml NaCi as their daily meal for 3 weeks. The different dose of P. americana aqueous extract, reduced blood pressures of the hypertensive rats. Increase in the lipid profile parameters were observed in all the treated groups. These results suggest that the use of ethanol seed extract of this plant in the treatment of hypertension may produce an unfavourable lipid profile at the concentrations of equal to or greater than 200 mg/kg dose level.