Phytochemical And Blood Sugar Lowering Properties Of Uziza (Piper Gunieese') And Utazi (Gongronema Latilodium) Leaves Extracts Using Diabetic Rats:- nyanso Anita
ABSTRACT
Phytochemical and blood sugar lowering
properties of uziza {Piper gunieese) and utazi (Gongronema latilodium) leaves
extracts using diabetic rats was studied. Ethanoic extraction was performed on
the different leaf samples to obtain utazi leaf extract and ukazi leaf
extracts. The uziza leaf and utazi leaf extracts were analysed for
phytochemicals using standard method. The leaves extract were used in the
treatment of alloxan induced diabetic rats. Acute toxicity (LD50) tests were
carried out on the treated rats. The effects ofthe leaf extracts on acute
toxicity, acute and sub-acute hypoglycemic study, body weight and lipid profile
were also investigated. Findings showed that phytochemical properties ofthe
leaves ranged from 2.06 to 9.44% % flavonoid, 3.59 to 9.11 % alkaloid, 1.95 to
18.76 % saponin, 0.07 to 0.28 % phytate. Acute and sub-acute studies on blood
glucose level revealed that 800 mg/kg of the leaf extracts significantly
(P<0.05) lowered blood glucose level in diabetic rats and compared
favourably with effect of Glibenclamide (5mg/kg), a standard hypoglycaemic drug.
The study shows that there was higher body weight gain in diabetic rats from
the extract of400mg and 800mg of utazi The extract significantly (P<0.05)
increased the levels of triglycerides, low density lipoprotein cholesterol,
very low density lipoprotein cholesterol and total cholesterol but increased
the levels ofhigh density lipoprotein cholesterol in diabetic rats. These
results suggest that uziza leaf and utazi leaves contain potent hypoglycaemic
and hypolipidemic agents capable of reversing hyperglycaemia and haematological
abnormalities associated with the pathophysiology of diabetes mellitus.
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MICHAEL, U (2026). Phytochemical And Blood Sugar Lowering Properties Of Uziza (Piper Gunieese') And Utazi (Gongronema Latilodium) Leaves Extracts Using Diabetic Rats:- nyanso Anita. Mouau.afribary.org: Retrieved Apr 23, 2026, from https://repository.mouau.edu.ng/work/view/phytochemical-and-blood-sugar-lowering-properties-of-uziza-piper-gunieese-and-utazi-gongronema-latilodium-leaves-extracts-using-diabetic-rats-nyanso-anita-7-2
UNIVERSITY, MICHAEL. "Phytochemical And Blood Sugar Lowering Properties Of Uziza (Piper Gunieese') And Utazi (Gongronema Latilodium) Leaves Extracts Using Diabetic Rats:- nyanso Anita" Mouau.afribary.org. Mouau.afribary.org, 23 Apr. 2026, https://repository.mouau.edu.ng/work/view/phytochemical-and-blood-sugar-lowering-properties-of-uziza-piper-gunieese-and-utazi-gongronema-latilodium-leaves-extracts-using-diabetic-rats-nyanso-anita-7-2. Accessed 23 Apr. 2026.
UNIVERSITY, MICHAEL. "Phytochemical And Blood Sugar Lowering Properties Of Uziza (Piper Gunieese') And Utazi (Gongronema Latilodium) Leaves Extracts Using Diabetic Rats:- nyanso Anita". Mouau.afribary.org, Mouau.afribary.org, 23 Apr. 2026. Web. 23 Apr. 2026. < https://repository.mouau.edu.ng/work/view/phytochemical-and-blood-sugar-lowering-properties-of-uziza-piper-gunieese-and-utazi-gongronema-latilodium-leaves-extracts-using-diabetic-rats-nyanso-anita-7-2 >.
UNIVERSITY, MICHAEL. "Phytochemical And Blood Sugar Lowering Properties Of Uziza (Piper Gunieese') And Utazi (Gongronema Latilodium) Leaves Extracts Using Diabetic Rats:- nyanso Anita" Mouau.afribary.org (2026). Accessed 23 Apr. 2026. https://repository.mouau.edu.ng/work/view/phytochemical-and-blood-sugar-lowering-properties-of-uziza-piper-gunieese-and-utazi-gongronema-latilodium-leaves-extracts-using-diabetic-rats-nyanso-anita-7-2