Effect Of The Ethanol Extract Of The Leaves Of Annona Muricata On Aspirin--Induced Gastric Ulcer In Rats:- Okoro Kenneth I
ABSTRACT
Over
the years, many plants have been the bases for medicinal treatment and such
plants are still widely in use today such as the leaves of A. muricata. The
objective of this work were to determine the phytochemical constituents, acute
toxicity and lethality and effects of the ethanol extract of the leaves of A.
muricata on ulcer index and curative ratio. The preliminary phytochemical
screening revealed that the extract contained alkaloids, flavoniods, tannins,
saponins, carbohydrates, glycosides, proteins, steroids, terpenoids and fats
and oil but resins, reducing sugars and acidic compounds were not detected in
the extract. The extract at the tested doses [I 00, 200 and 400 mg/kg body
weight (b.w)] caused significant (p <0.05) and dosedependent decreases in
the ulcer indices of the rat in the test groups compared to the value obtained
for the rats in the positive control group. The mean curative ratios of the
extract were remarkable and dose-dependent. The effects of the extract at the
dose of 400 mg/kg b. w were comparable to those of the standard anti-ulcer
drug, ranitidine at the dose of 150 mg/kg b.w. In conclusion, the experimental
data justify the use of leaves of A. muricata in folk medicine for the cure of
gastric ulcer.
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OKOROKENNETHIKECHUKWU, O (2024). Effect Of The Ethanol Extract Of The Leaves Of Annona Muricata On Aspirin--Induced Gastric Ulcer In Rats:- Okoro Kenneth I. Mouau.afribary.org: Retrieved Dec 21, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-aspirin-induced-gastric-ulcer-in-rats-okoro-kenneth-i-7-2
OKOROKENNETHIKECHUKWU, OKOROKENNETHIKECHUKWU. "Effect Of The Ethanol Extract Of The Leaves Of Annona Muricata On Aspirin--Induced Gastric Ulcer In Rats:- Okoro Kenneth I" Mouau.afribary.org. Mouau.afribary.org, 09 Dec. 2024, https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-aspirin-induced-gastric-ulcer-in-rats-okoro-kenneth-i-7-2. Accessed 21 Dec. 2024.
OKOROKENNETHIKECHUKWU, OKOROKENNETHIKECHUKWU. "Effect Of The Ethanol Extract Of The Leaves Of Annona Muricata On Aspirin--Induced Gastric Ulcer In Rats:- Okoro Kenneth I". Mouau.afribary.org, Mouau.afribary.org, 09 Dec. 2024. Web. 21 Dec. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-aspirin-induced-gastric-ulcer-in-rats-okoro-kenneth-i-7-2 >.
OKOROKENNETHIKECHUKWU, OKOROKENNETHIKECHUKWU. "Effect Of The Ethanol Extract Of The Leaves Of Annona Muricata On Aspirin--Induced Gastric Ulcer In Rats:- Okoro Kenneth I" Mouau.afribary.org (2024). Accessed 21 Dec. 2024. https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-aspirin-induced-gastric-ulcer-in-rats-okoro-kenneth-i-7-2