Nephro-Protective Activity Of Methanol Extract Of Bombax Buonopenzense (P. Beauv) In Paracetamol Induced Toxicity Of Wistar Albino Rat

ABSTRACT

Bombax buonoponenzes (P.Beauv) is a medicinal plant used in treating migraine headache and it is used also to increase lactation in nursing mothers as well as other uses. The present study was aimed at investigating the nephroprotective activity of methanol leave extract of Bombax buonopozens in wistar albino rats. The Biochemical parameters evaluated includes urea and creatinine. From the result, it was revealed that prolong use of methanol extract of Bombax buonopozense leaves extract causes significant decreases (p<0.05) in creatinine and urea level suggested Bombax buonoponenzes plays a vital role in detoxification and nephro-protection

TABLE OF CONTENTS

TITLE PAGE ﾿ i

CERTIFICATION ﾿ ii ﾿

DEDICATION ﾿ iii ﾿

ACKNOWLEDGEMENT ﾿ iv ﾿

TABLE OF CONTENTS ﾿ v ﾿

LIST OF TABLES ﾿ vi ﾿

LIST OF FIGURES ﾿ vii ﾿

ABSTRACT ﾿ viii

CHAPTER ONE

1.0 ﾿ Introduction ﾿ 1

1.1   Aim of the Study ﾿ 4

1.2   Objective of the Study ﾿ 4

1.3   Justification of the Study ﾿ 4

1.4   Scope of the Study ﾿ 5

CHAPTER TWO

2.1 ﾿ Literature Review ﾿ 6

2.2       Origin ﾿ 10

2.3 ﾿ Botanical Description Of Bombax Buonoponenzes (P.Beauv) ﾿             10

2.4    ﾿ Uses ﾿ 10

CHAPTER THREE

Materials And Method ﾿

3.1      Plant Sample                                    ﾿ 13

3.2     Preparation Of The Extract ﾿ 13

3.3     Experimental Animals ﾿ 14

3.4     Experimental Design ﾿ 14

3.5     Biochemical Estimation ﾿ 15

CHAPTER FOUR

4.0       Result ﾿ 16

4.1      Nephroprotective Effect of Methanol Leaf extract o Bombax buonopoenses

           (P-Beauv) on Serum Creatinine level of Paracetamol induced Wister Rats                22

CHAPTER FIVE

Conclusion And Recommendation

5.3     Recommendation ﾿ 18

References

Appendix