The Effect Of Stem Bark Of Ficus Glumosa Extract On Alloxan Induced Hyperglycaemic Rat (Antoxidant Enzyme And Lipid Peroxidation)
ABSTRACT
Ficus glumosa (Moraceae), commc nly known as African rock fig is used in the traditional folk medicine for t e treatment of many diseases such as hyperglycaemia. This study evaluated the subacute anti-diabetic and in vivo antioxidant effects of the methan Aic extract of Ficus gluinosa stem bark on alloxan-induced hyperglycaemic ras. The extract produced its optimum effect at the dose of 62.5 mg/kg, since ir.crease beyond this did not produce further reduction in FBS level, rather caused a reduced catalase activity. The extract caused significant (p<O.OS) dose-dc 9endent decrease in the level of thiobarbituric acid reactive substance (TBARS) v hen compared with the distilled water-treated group. The extract (62.5 mg/kg) oroduced a significant (p<O.05) increase in catalase activities when compare to the negative control. This effect was comparable to glibenclarnide (2.0 mg/kg). The results obtained in this study suggest that F. glumosa has antidiaL tic and antioxidant activities which may be of benefit in management of hyerglycaemia and prevention of diabetic complications.
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ELENDU, S (2021). The Effect Of Stem Bark Of Ficus Glumosa Extract On Alloxan Induced Hyperglycaemic Rat (Antoxidant Enzyme And Lipid Peroxidation) . Mouau.afribary.org: Retrieved Nov 26, 2024, from https://repository.mouau.edu.ng/work/view/the-effect-of-stem-bark-of-ficus-glumosa-extract-on-alloxan-induced-hyperglycaemic-rat-antoxidant-enzyme-and-lipid-peroxidation-7-2
SARACHI, ELENDU. "The Effect Of Stem Bark Of Ficus Glumosa Extract On Alloxan Induced Hyperglycaemic Rat (Antoxidant Enzyme And Lipid Peroxidation) " Mouau.afribary.org. Mouau.afribary.org, 23 Jun. 2021, https://repository.mouau.edu.ng/work/view/the-effect-of-stem-bark-of-ficus-glumosa-extract-on-alloxan-induced-hyperglycaemic-rat-antoxidant-enzyme-and-lipid-peroxidation-7-2. Accessed 26 Nov. 2024.
SARACHI, ELENDU. "The Effect Of Stem Bark Of Ficus Glumosa Extract On Alloxan Induced Hyperglycaemic Rat (Antoxidant Enzyme And Lipid Peroxidation) ". Mouau.afribary.org, Mouau.afribary.org, 23 Jun. 2021. Web. 26 Nov. 2024. < https://repository.mouau.edu.ng/work/view/the-effect-of-stem-bark-of-ficus-glumosa-extract-on-alloxan-induced-hyperglycaemic-rat-antoxidant-enzyme-and-lipid-peroxidation-7-2 >.
SARACHI, ELENDU. "The Effect Of Stem Bark Of Ficus Glumosa Extract On Alloxan Induced Hyperglycaemic Rat (Antoxidant Enzyme And Lipid Peroxidation) " Mouau.afribary.org (2021). Accessed 26 Nov. 2024. https://repository.mouau.edu.ng/work/view/the-effect-of-stem-bark-of-ficus-glumosa-extract-on-alloxan-induced-hyperglycaemic-rat-antoxidant-enzyme-and-lipid-peroxidation-7-2