Screen Of Sputum Samples From Patients Attending Public Hospitals In Abia State For Extended Spectrum Beta-Lactamase Producing Klebsiella Pneumoniae
ABSTRACT
The aim of the study was to detect extended spectrum B-lactamase (ESBL) in Klebsiella pneumoniae isolated from patients’ sputum attending public hospitals in Abia State. A total of 64 sputum specimens were collected from public hospitals in Abia State, majorly; Federal Medical Centre, Umuahia, Abia State Specialist Hospital, Umuahia and Seventh Day Adventists Hospital, Aba between the period of June and September 2017. Bacteriological tests of sputum specimens were performed for Klebsiella pneumoniae including inoculation on MacConkey agar and blood agar. The identity of the isolates was confirmed by biochemical tests. Out of 64 sputum specimens, 21 (32%) Klebsiella pneumoniae were recovered from patients’ sputum. Susceptibility test were carried out for each Isolate and samples 14, 55, 58 and 63 had highest susceptibility and Ceftazidime (CAZ 30µg), gentamicin (GEN 10µg), Ofloxacin (OFL 5µg) Nitrofurantoin (NIT 300µg) and Aztreonam (ATM 30µg) shows the highest susceptibility pattern. While Ciprofloxacin (CPR 5µg), Augumentin (AUG 30µg) and Ceftriaxone (30µg) showed the lowest susceptibility pattern. Screening tests for ESBLs were performed against the 21 Isolates and 15 were sensitive while 6 were resistant. Double-disc synergy test (DDST) was done for this 15 isolates and 9 were positive and 6 were negative. This study showed that Klesiella pneumoniae is considered to be one of ESBLs producers.
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EZEAMA, D (2022). Screen Of Sputum Samples From Patients Attending Public Hospitals In Abia State For Extended Spectrum Beta-Lactamase Producing Klebsiella Pneumoniae. Mouau.afribary.org: Retrieved Nov 15, 2024, from https://repository.mouau.edu.ng/work/view/screen-of-sputum-samples-from-patients-attending-public-hospitals-in-abia-state-for-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-7-2
DAVID, EZEAMA. "Screen Of Sputum Samples From Patients Attending Public Hospitals In Abia State For Extended Spectrum Beta-Lactamase Producing Klebsiella Pneumoniae" Mouau.afribary.org. Mouau.afribary.org, 17 Feb. 2022, https://repository.mouau.edu.ng/work/view/screen-of-sputum-samples-from-patients-attending-public-hospitals-in-abia-state-for-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-7-2. Accessed 15 Nov. 2024.
DAVID, EZEAMA. "Screen Of Sputum Samples From Patients Attending Public Hospitals In Abia State For Extended Spectrum Beta-Lactamase Producing Klebsiella Pneumoniae". Mouau.afribary.org, Mouau.afribary.org, 17 Feb. 2022. Web. 15 Nov. 2024. < https://repository.mouau.edu.ng/work/view/screen-of-sputum-samples-from-patients-attending-public-hospitals-in-abia-state-for-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-7-2 >.
DAVID, EZEAMA. "Screen Of Sputum Samples From Patients Attending Public Hospitals In Abia State For Extended Spectrum Beta-Lactamase Producing Klebsiella Pneumoniae" Mouau.afribary.org (2022). Accessed 15 Nov. 2024. https://repository.mouau.edu.ng/work/view/screen-of-sputum-samples-from-patients-attending-public-hospitals-in-abia-state-for-extended-spectrum-beta-lactamase-producing-klebsiella-pneumoniae-7-2