ABSTRACT
Sickle
cell disease is a group of diseases inherited through the gene and it affects
the haemoglobin in the red blood cell. This study investigated the aqueous
methanol root bark extract of Musanga cecropioides for possible in vitro
anti-sickling effects and also determined the effect of Musanga cecropioides
root bark extract on the solubility, polymerization, sickling inhibition,
sickling Reversal, osmotic fragility rate of sickle cell haemoglobin and to be
compared with para amino benzoic acid. Sickle cell blood was collected from
sickle cell disease patients with subsequent addition of 2% sodium
metabisulphite to cause more sickling. Varying concentrations ofthe Musanga
cecropioides root bark extracts of (50% and 25%) were added to the pre-treated
blood for these in vitro assays. The results showed that the extract of Musanga
cecropioides root bark extract significantly (P < 0.05) inhibited sickling,
polymerization, increase solubility, increase fe2+/fe3+ etc at all
concentrations with the highest percentage inhibition of 80± 17.36, reversed
sickled erythrocytes at all concentrations with the highest percent- age
reversal of 83.3 ± 5.8 and significantly (P < 0.05) inhibited polymerisation
at all concentrations used in comparison to the parallel control. The extract
of Musanga cecropioides root bark extract significantly (P < 0.05) increased
the solubility of sickle haemoglobin at 50% and 25% concentrations, increased
Fe2+/Fe3+ ratio from 12.32 (control) to 55.63 (50% concentration). Therefore,
aqueous methanol extract of Musanga cecropioides root bark has an anti-sickling
properties as compared with para amino benzoic acid.
DIKE, D (2024). Potential Of Aqueous Methanol Extract Of Musanga Cecropioides Root Bark As Anti-Sickling Age:- Dike, Maria-Goretti A. Mouau.afribary.org: Retrieved Dec 13, 2024, from https://repository.mouau.edu.ng/work/view/potential-of-aqueous-methanol-extract-of-musanga-cecropioides-root-bark-as-anti-sickling-age-dike-maria-goretti-a-7-2
DIKE, DIKE. "Potential Of Aqueous Methanol Extract Of Musanga Cecropioides Root Bark As Anti-Sickling Age:- Dike, Maria-Goretti A" Mouau.afribary.org. Mouau.afribary.org, 13 Nov. 2024, https://repository.mouau.edu.ng/work/view/potential-of-aqueous-methanol-extract-of-musanga-cecropioides-root-bark-as-anti-sickling-age-dike-maria-goretti-a-7-2. Accessed 13 Dec. 2024.
DIKE, DIKE. "Potential Of Aqueous Methanol Extract Of Musanga Cecropioides Root Bark As Anti-Sickling Age:- Dike, Maria-Goretti A". Mouau.afribary.org, Mouau.afribary.org, 13 Nov. 2024. Web. 13 Dec. 2024. < https://repository.mouau.edu.ng/work/view/potential-of-aqueous-methanol-extract-of-musanga-cecropioides-root-bark-as-anti-sickling-age-dike-maria-goretti-a-7-2 >.
DIKE, DIKE. "Potential Of Aqueous Methanol Extract Of Musanga Cecropioides Root Bark As Anti-Sickling Age:- Dike, Maria-Goretti A" Mouau.afribary.org (2024). Accessed 13 Dec. 2024. https://repository.mouau.edu.ng/work/view/potential-of-aqueous-methanol-extract-of-musanga-cecropioides-root-bark-as-anti-sickling-age-dike-maria-goretti-a-7-2