ABSTRACT

The ethanoic and aqueous extract of seeds of Alligator pepper, Avocado pear, Bitter kola and Paw-paw were subjected to phytochemical screening and antimicrobial activity study. The study indicates that the extract of the seeds of Bitter kola (ethanoic) was active against all the test organisms at lOOmg/ml zone of inhibition ranging from 8.33mm in Staphylococcus aureus and Pseudomonas aureginosa to 11mm in Salmonella typhi. The ethanoic extract of Paw-paw inhibited Pseudomonas aureginosa the most at lOOmg/ml at the diameter of 10.33mm. The aqueous extract of Avocado pear seed best inhibits Pseudomonas aureginosa at 150mg/ml at 8.jjmm, Alligator pepper aqueous extract inhibits two test organisms at 150mg/ml ranging from 9mm to 9.67mm in Staphylococcus aureus and Bacillus substilis respectively. The result reveals the presence of compounds in the seed extract and were found to be a rich source of phytochemical. The studies on Bitter kola, Paw-paw, Avocado pear and Alligator pepper extract exhibited their antimicrobial potential which could be exploited for pharmaceutical purposes and therapeutic potentials. The minimum inhibitory concentration (MIC) of extracts were determined for the various organism. Staphylococcus aureus has a remarkable inhibition with the aqueous extract of Carica papaya at the diameter 8.33±1.53 as with ethanoic extract of Aframomum against the four test seed sample. viii 1 inhibited with the aqueous extract ofPersea Americana at the diameter of 8.663+1.53 against Garcinia kola that inhibits Salmonella typhi at the diameter of 20.333+1.15.Bacillus substilis was inhibited at a good diameter of 1.667+1.15 with aqueous extract of Carica papaya against ethanoic extract of Garcinia kola at the diameter of 21.000± 2.00 and Pseudomonas aeroginosa was inhibited with the aqueous extract of Aframomum melegueta against a high diameter of 19.667+ 1.15. The standard antibiotic used showed the highest diameter ofinhibition constituent melegueta that inhibits staphylococcus aureus at 17.667+1.53, Salmonella typhi was best inhibited with the aqueous extract ofPersea Americana at the diameter of 8.663+1.53 against Garcinia kola that inhibits Salmonella typhi at the diameter of 20.333+1.15.Bacillus substilis was inhibited at a good diameter of 1.667+1.15 with aqueous extract of Carica papaya against ethanoic extract of Garcinia kola at the diameter of 21.000± 2.00 and Pseudomonas aeroginosa was inhibited with the aqueous extract of Aframomum melegueta against a high diameter of 19.667+ 1.15. The standard antibiotic used showed the highest diameter ofinhibition constituent against the four test seed sample.