ABSTRACT
This study investigated
the protective effect of methanol extract of Piper nigrum leaf against cadmium
toxicities in rats kidney. Twenty (28) wistar albino rats were divided into
four groups (n=7 rats/group). Rats in group 1 were given feed and water, rats
in group 2 were orally adiriinistered 500mg/kg bwt. of Piper nigrum leaf
extract, group 3 were intraperitoneally administered 1.2mg/kg bwt cadmium
chloride and group 4 were administered 1.2mg/kg bwt cadmium chloride and
500mg/kg bwt. Piper nigrum leaf extract daily for 14 days. The animals were
sacrificed after an experimental period of two weeks. Results of the study
revealed significantly (p<0.05) higher serum creatinine and urea
concentration in rats exposed to cadmium alone (group 3) compared to the
control group (1), which could suggest an obvious interference with normal
kidney glomerular hyper filtration function. There was no significant
(p>0.05) decrease in uric acid concentration in the group treated with cadmium
alone (group 3) when compared to the control group (1), therefore, it is only
assumptive whether cadmium may have trigger some adverse effects thereby
compromising the integrity ofthe functional capacity ofthe kidney. There was a
significant (p<0.05) decrease in urea and creatinine concentration of group
4 rats when compared with group 3 rats. Also there was a significant increase
in sodium and chloride ions of group 4 rats when compared with group 3 rats.
These suggest a protective potential of the plant. Sodium concentration of rats
in groups 2 and 3 significantly (p><0.05) reduced compared to the control
group (group 1) which could suggest hyponatremia which may have resulted when
the water intake exceeded water output through the kidney. Potassium concentration
in the cadmium alone (group 3) treated group when compared to the control group
(1) could support a suggestive renal damage. The significant (p><0.05)
increase in chloride excretion observed in group 3 when compared to group 1 may
suggest an occurrence of diarrhea which may have been triggered by the toxic
effect of cadmium. The study therefore revealed that cadmium chloride is
nephrotoxic and a relative ameliorative potential of the leaf extract as no
holistic or absolute protection was conferred on the kidneys functional
integrity.>
IBEABUCHI, I (2024). Methanol Extract Of Piper Nigrum Leaf Protects Against Cadmium Toxicities In Rats, Kidney:- Ibeabuchi, Nneoma J. Mouau.afribary.org: Retrieved Sep 08, 2024, from https://repository.mouau.edu.ng/work/view/methanol-extract-of-piper-nigrum-leaf-protects-against-cadmium-toxicities-in-rats-kidney-ibeabuchi-nneoma-j-7-2
IBEABUCHI, IBEABUCHI. "Methanol Extract Of Piper Nigrum Leaf Protects Against Cadmium Toxicities In Rats, Kidney:- Ibeabuchi, Nneoma J" Mouau.afribary.org. Mouau.afribary.org, 25 Mar. 2024, https://repository.mouau.edu.ng/work/view/methanol-extract-of-piper-nigrum-leaf-protects-against-cadmium-toxicities-in-rats-kidney-ibeabuchi-nneoma-j-7-2. Accessed 08 Sep. 2024.
IBEABUCHI, IBEABUCHI. "Methanol Extract Of Piper Nigrum Leaf Protects Against Cadmium Toxicities In Rats, Kidney:- Ibeabuchi, Nneoma J". Mouau.afribary.org, Mouau.afribary.org, 25 Mar. 2024. Web. 08 Sep. 2024. < https://repository.mouau.edu.ng/work/view/methanol-extract-of-piper-nigrum-leaf-protects-against-cadmium-toxicities-in-rats-kidney-ibeabuchi-nneoma-j-7-2 >.
IBEABUCHI, IBEABUCHI. "Methanol Extract Of Piper Nigrum Leaf Protects Against Cadmium Toxicities In Rats, Kidney:- Ibeabuchi, Nneoma J" Mouau.afribary.org (2024). Accessed 08 Sep. 2024. https://repository.mouau.edu.ng/work/view/methanol-extract-of-piper-nigrum-leaf-protects-against-cadmium-toxicities-in-rats-kidney-ibeabuchi-nneoma-j-7-2