Anti Hypertensive Efficacy Of Methanol Extract Of Carica Papaya Seed In Sodium Chloride Induced Albino Rats:- Ariwa, Nelson C
ABSTRACT
The study evaluated the antihypertensive effect
of methanolic extract of Carica papaya seed in sodium chloride induced albino
rats. Twenty two (22) wister albino ratserving as the experimental animals were
assigned to 6 groups of4 rats per group. Group 2,3,4,5 and 6 were induced
hypertension by administering sodium chloride at different dosage according to
their body weight. Group 2 served as a negative control (without treatment)
while group 1 served as positive control. Group 3 received standard drug
(captopril) as treatment while group 4,5 and 6 received extract at different
dosage for treatment (100mg/kg,200mg/kg,400mg/kg) respectively. The
administration was done along side with treatment for 7days. The result showed
the administration of sodium chloride lead to high pulse rate of the untreated
group, thereby lowered by drug and extract treatment, and also there was a
significant (p< 0.05) dose-dependent decrease of hypertension risk in the
groups given the extract and drug compared to untreated group reducing (serum
sodium level), CK level and LDH level. But in comparison ofthe extract
treatment and drug treatment was more active than the drug (captopril). This
study shows the relevance of Carica papaya seed in use to prevent and maintain
high blood pressure and also antihypertensive folkloric medicine.
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ARIWA (2026). Anti Hypertensive Efficacy Of Methanol Extract Of Carica Papaya Seed In Sodium Chloride Induced Albino Rats:- Ariwa, Nelson C. Mouau.afribary.org: Retrieved Mar 13, 2026, from https://repository.mouau.edu.ng/work/view/anti-hypertensive-efficacy-of-methanol-extract-of-carica-papaya-seed-in-sodium-chloride-induced-albino-rats-ariwa-nelson-c-7-2
ARIWA. "Anti Hypertensive Efficacy Of Methanol Extract Of Carica Papaya Seed In Sodium Chloride Induced Albino Rats:- Ariwa, Nelson C" Mouau.afribary.org. Mouau.afribary.org, 13 Mar. 2026, https://repository.mouau.edu.ng/work/view/anti-hypertensive-efficacy-of-methanol-extract-of-carica-papaya-seed-in-sodium-chloride-induced-albino-rats-ariwa-nelson-c-7-2. Accessed 13 Mar. 2026.
ARIWA. "Anti Hypertensive Efficacy Of Methanol Extract Of Carica Papaya Seed In Sodium Chloride Induced Albino Rats:- Ariwa, Nelson C". Mouau.afribary.org, Mouau.afribary.org, 13 Mar. 2026. Web. 13 Mar. 2026. < https://repository.mouau.edu.ng/work/view/anti-hypertensive-efficacy-of-methanol-extract-of-carica-papaya-seed-in-sodium-chloride-induced-albino-rats-ariwa-nelson-c-7-2 >.
ARIWA. "Anti Hypertensive Efficacy Of Methanol Extract Of Carica Papaya Seed In Sodium Chloride Induced Albino Rats:- Ariwa, Nelson C" Mouau.afribary.org (2026). Accessed 13 Mar. 2026. https://repository.mouau.edu.ng/work/view/anti-hypertensive-efficacy-of-methanol-extract-of-carica-papaya-seed-in-sodium-chloride-induced-albino-rats-ariwa-nelson-c-7-2