ABSTRACT
In
Nigeria, Gnetum africamnn is used by different communities to prepared various
diets and also has been reported to have some nutritional and health benefits
with low or no scientific evidence. The aim was to study the immunomodulatory
activity of G. afiicamim ethanol leaf extract in Wistar albino rats. A total of
12 wistar albino rats were used fbr this study and grouped into 3 (n=4). They
were acclimatized fbr a period of 1 week and fed vital growers mash and water
ad libitum. Group 1 (normal control) was administered feed and water ad libitum
while group 2 (positive control) was administered pyrogallol and group 3
(treated group) was administered pyrogallol and 400 mg/kg ethanol extract of G.
Afiucamun. The study lasted fbr a period of 28 days after which they were
sacrificed and serum collected fbr further biochemical assays.
Haemagglutination titre, haematological assays and serum antioxidants were
assayed using standard methods. Results of the experiment shows a significant
(p<0.05) increase in primary and secondary antibodies when the treated group
was compared with the positive control while haematological results show a
significant (p<0.05) increase in RBC, PCV and HB when the treated group was
compared against the positive control. Furthermore, the serum antioxidant assay
showed that the treated group expressed significant (p<0.05) increase in
catalase and GPx activity and a significant (p<0.05) decrease in MDA
concentration when compared with the positive control. In conclusion, G.
Africanum can be seen to have immunostimulatoiy potentials.
ONYEMA, O (2024). Immunomodulatory Effect Of Methanol Extract Of Giietum Africanum In Wistar Albino Rats:- Onyema, Uchenna B.. Mouau.afribary.org: Retrieved Sep 08, 2024, from https://repository.mouau.edu.ng/work/view/immunomodulatory-effect-of-methanol-extract-of-giietum-africanum-in-wistar-albino-rats-onyema-uchenna-b-7-2
ONYEMA, ONYEMA. "Immunomodulatory Effect Of Methanol Extract Of Giietum Africanum In Wistar Albino Rats:- Onyema, Uchenna B." Mouau.afribary.org. Mouau.afribary.org, 25 Mar. 2024, https://repository.mouau.edu.ng/work/view/immunomodulatory-effect-of-methanol-extract-of-giietum-africanum-in-wistar-albino-rats-onyema-uchenna-b-7-2. Accessed 08 Sep. 2024.
ONYEMA, ONYEMA. "Immunomodulatory Effect Of Methanol Extract Of Giietum Africanum In Wistar Albino Rats:- Onyema, Uchenna B.". Mouau.afribary.org, Mouau.afribary.org, 25 Mar. 2024. Web. 08 Sep. 2024. < https://repository.mouau.edu.ng/work/view/immunomodulatory-effect-of-methanol-extract-of-giietum-africanum-in-wistar-albino-rats-onyema-uchenna-b-7-2 >.
ONYEMA, ONYEMA. "Immunomodulatory Effect Of Methanol Extract Of Giietum Africanum In Wistar Albino Rats:- Onyema, Uchenna B." Mouau.afribary.org (2024). Accessed 08 Sep. 2024. https://repository.mouau.edu.ng/work/view/immunomodulatory-effect-of-methanol-extract-of-giietum-africanum-in-wistar-albino-rats-onyema-uchenna-b-7-2