Haematology Profile Of Male Wistar Rats Administered With Methanolic Extract Of Citrullus Lanatus (Water Melon) And Thioacetamide (Taa)
ABSTRACT
The present study evaluated the effect of methanol extract of the rind of Citruuslanatus on some haematological parameters in rats exposed to thioacetarnide. Ten wistar albino rats having an average weight of 100 g were used in this study and they were divided into five groups each consisting of five rats. Group 1 received thioacetamide (300 mg/kg), while Group 2 received 300 mg/kg of Thioacetamidc (TAA) and 250mg/kg of methanol extract of the rind of Citrullus lanatus extract before 7 days. All animals received dextrose water and ringer lactate solutions (1 0 mg/kg/day) intraperitoneally to prevent renal failure, hypoglycemia and ci ectro lyte imbalance till the end of the experiment. Treatment were given by oral administration of methanol extract of the rind of Citrullus lanatus which lasted for 7 days. At the end of the 7th day, rats in each groups were sacrificed and blood samples were collected by ocular puncture for the determination of hacmatological parameters which include: PCV, RBC, TWBC, HB, MCV, MCH, MCI-IC. Results from this study showed a significant increase in (p <0.05) MCV, 1-1B, MCII and MCHC values (Group 1) as well as a significant decrease (p<O.O5) in 'T'WBC, RBC and PCV values (Group 2). It was observed that the animals responded differently after being treated with the methanolic extract of the rind of Citrullus lanatus, which shows that this plant extract can be used as an effective agent in normalizing blood cell indices after TAA induce toxicity.
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AGU, C (2021). Haematology Profile Of Male Wistar Rats Administered With Methanolic Extract Of Citrullus Lanatus (Water Melon) And Thioacetamide (Taa). Mouau.afribary.org: Retrieved Nov 17, 2024, from https://repository.mouau.edu.ng/work/view/haematology-profile-of-male-wistar-rats-administered-with-methanolic-extract-of-citrullus-lanatus-water-melon-and-thioacetamide-taa-7-2
CHIBUGO, AGU. "Haematology Profile Of Male Wistar Rats Administered With Methanolic Extract Of Citrullus Lanatus (Water Melon) And Thioacetamide (Taa)" Mouau.afribary.org. Mouau.afribary.org, 15 Jun. 2021, https://repository.mouau.edu.ng/work/view/haematology-profile-of-male-wistar-rats-administered-with-methanolic-extract-of-citrullus-lanatus-water-melon-and-thioacetamide-taa-7-2. Accessed 17 Nov. 2024.
CHIBUGO, AGU. "Haematology Profile Of Male Wistar Rats Administered With Methanolic Extract Of Citrullus Lanatus (Water Melon) And Thioacetamide (Taa)". Mouau.afribary.org, Mouau.afribary.org, 15 Jun. 2021. Web. 17 Nov. 2024. < https://repository.mouau.edu.ng/work/view/haematology-profile-of-male-wistar-rats-administered-with-methanolic-extract-of-citrullus-lanatus-water-melon-and-thioacetamide-taa-7-2 >.
CHIBUGO, AGU. "Haematology Profile Of Male Wistar Rats Administered With Methanolic Extract Of Citrullus Lanatus (Water Melon) And Thioacetamide (Taa)" Mouau.afribary.org (2021). Accessed 17 Nov. 2024. https://repository.mouau.edu.ng/work/view/haematology-profile-of-male-wistar-rats-administered-with-methanolic-extract-of-citrullus-lanatus-water-melon-and-thioacetamide-taa-7-2