Glutathione Peroxidase Activity in the Serum and Liver Homogenate of Normal and Monosodium Glutamate-Intoxicated Rats Co-Treated with Artemeter And Lumafantrine:- Ezenwafor Nnaemeka R.
ABSTRACT
The present
study investigated the glutathione peroxidase activity in the serum and liver
homogenate of normal and monosodium glutamate-intoxicated rats co-treated with
artemeter and lumafantrine. 30 male wistar albino rats weighing 80-140g were
randomly sectioned into 6 groups(n=5), as follows: Normal group: feed and water
only; ALC therapeutic dose group: 0.17ml ALC, feed, and water; ALC overdose
group: ALC therapeutic dose multiplied by 5(0.8ml), teed and water; MSG-only
group: MSG (8mg/g bodyweight), feed and water; MSG+ALC therapeutic dose group:
ALC therapeutic dose(0.17ml) + MSG (8mg/g bodyweight), feed and water;MSG+ALC
(overdose): ALC (overdose) (0.85) + MSG (8mg/g bodyweight), feed and water.
After 7-days of treatment the rats were humanely sacrificed and blood samples
and liver tissue collected for glutathione peroxidase assay. Results showed
less than normal liver glutathione peroxidase activity in all treatments in the
order: ALC (overdose) (19.72±1.59)> ALC (therapeutic dose) (17.51±1.56)>
MSG+ALC (therapeutic dose) (15.77±0.55)> MSG+ALC (overdose) (15.56±0.70)>
MSG-only rats (13.32+1.21). Mean serum glutathione peroxidase activity of
MSG-only rats (1.67+0.13) was significantly (P<0.05) lower than Normal
(4.60+0.36), ALC (therapeutic dose) (3.82+0.38), ALC (overdose) (4.62+0.22),
MSG+ALC (therapeutic dose) (3.66+0.37), and MSG+ALC (overdose) (7.50+0.33)
groups respectively. Liver homogenates showed higher Gpx activities than serum.
The study confirmed a possible deleterious effect of MSG and ALC administration
on glutathione peroxidase activity in serum and liver homogenates as evidenced
by reduced Gpx activities especially in liver ofMSG-treated rats, however
further studies will help explain the paradoxical increase in serum Gpx
activity seen in ALC overdose treated rats.
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EZENWAFOR, R (2023). Glutathione Peroxidase Activity in the Serum and Liver Homogenate of Normal and Monosodium Glutamate-Intoxicated Rats Co-Treated with Artemeter And Lumafantrine:- Ezenwafor Nnaemeka R.. Mouau.afribary.org: Retrieved Nov 17, 2024, from https://repository.mouau.edu.ng/work/view/glutathione-peroxidase-activity-in-the-serum-and-liver-homogenate-of-normal-and-monosodium-glutamate-intoxicated-rats-co-treated-with-artemeter-and-lumafantrine-ezenwafor-nnaemeka-r-7-2
RAYMOND, EZENWAFOR. "Glutathione Peroxidase Activity in the Serum and Liver Homogenate of Normal and Monosodium Glutamate-Intoxicated Rats Co-Treated with Artemeter And Lumafantrine:- Ezenwafor Nnaemeka R." Mouau.afribary.org. Mouau.afribary.org, 31 Oct. 2023, https://repository.mouau.edu.ng/work/view/glutathione-peroxidase-activity-in-the-serum-and-liver-homogenate-of-normal-and-monosodium-glutamate-intoxicated-rats-co-treated-with-artemeter-and-lumafantrine-ezenwafor-nnaemeka-r-7-2. Accessed 17 Nov. 2024.
RAYMOND, EZENWAFOR. "Glutathione Peroxidase Activity in the Serum and Liver Homogenate of Normal and Monosodium Glutamate-Intoxicated Rats Co-Treated with Artemeter And Lumafantrine:- Ezenwafor Nnaemeka R.". Mouau.afribary.org, Mouau.afribary.org, 31 Oct. 2023. Web. 17 Nov. 2024. < https://repository.mouau.edu.ng/work/view/glutathione-peroxidase-activity-in-the-serum-and-liver-homogenate-of-normal-and-monosodium-glutamate-intoxicated-rats-co-treated-with-artemeter-and-lumafantrine-ezenwafor-nnaemeka-r-7-2 >.
RAYMOND, EZENWAFOR. "Glutathione Peroxidase Activity in the Serum and Liver Homogenate of Normal and Monosodium Glutamate-Intoxicated Rats Co-Treated with Artemeter And Lumafantrine:- Ezenwafor Nnaemeka R." Mouau.afribary.org (2023). Accessed 17 Nov. 2024. https://repository.mouau.edu.ng/work/view/glutathione-peroxidase-activity-in-the-serum-and-liver-homogenate-of-normal-and-monosodium-glutamate-intoxicated-rats-co-treated-with-artemeter-and-lumafantrine-ezenwafor-nnaemeka-r-7-2