Effects of the Ethanol Extract of the Leaves of A. muricata on Red Blood Cell (RBC) Count ofAspirin-ulcerated Rats:- Nwoche, Victor U.
ABSTRACT
Natural products especially those
derived from plants have been used to help mankind sustain health since the
dawn ofmedicine. Over the past century, the phytochemicals in plants have been
a pivotal pipeline for pharmaceutical discoveries. The objectives ofthis work
were to examine the phytochemical constituents, acute toxicity and lethality
and effect of the ethanol extract of the leaves ofA. muricata on the red blood
cell (RBC) count of aspirin-ulcerated rats. The qualitative phytochemical
analyses revealed the presence of alkaloids, flavonoids, tannins, saponins,
carbohydrates, glycosides, proteins, steroids, terpenoids and fats and oil.
Resins, reducing sugars and acidic compounds were not detected in the extract.
The extract was found to be safe even at a dose as high as 5000 mg/kg body
weight (b.w). The extract at the tested doses (100, 200 and 400 mg/kg b.w)
significantly (p < 0.05) and dose-dependently increased the RBC count ofthe
rats in the test groups compared to the value obtained for the rats in the
ulcer-untreated group. These implies that the leaves ofA. muricata may serve as
origin of anti-ulcer drug(s) in future.
0.0
-- (2023). Effects of the Ethanol Extract of the Leaves of A. muricata on Red Blood Cell (RBC) Count ofAspirin-ulcerated Rats:- Nwoche, Victor U.. Mouau.afribary.org: Retrieved Nov 17, 2024, from https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-a-muricata-on-red-blood-cell-rbc-count-ofaspirin-ulcerated-rats-nwoche-victor-u-7-2
--. "Effects of the Ethanol Extract of the Leaves of A. muricata on Red Blood Cell (RBC) Count ofAspirin-ulcerated Rats:- Nwoche, Victor U." Mouau.afribary.org. Mouau.afribary.org, 24 Oct. 2023, https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-a-muricata-on-red-blood-cell-rbc-count-ofaspirin-ulcerated-rats-nwoche-victor-u-7-2. Accessed 17 Nov. 2024.
--. "Effects of the Ethanol Extract of the Leaves of A. muricata on Red Blood Cell (RBC) Count ofAspirin-ulcerated Rats:- Nwoche, Victor U.". Mouau.afribary.org, Mouau.afribary.org, 24 Oct. 2023. Web. 17 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-a-muricata-on-red-blood-cell-rbc-count-ofaspirin-ulcerated-rats-nwoche-victor-u-7-2 >.
--. "Effects of the Ethanol Extract of the Leaves of A. muricata on Red Blood Cell (RBC) Count ofAspirin-ulcerated Rats:- Nwoche, Victor U." Mouau.afribary.org (2023). Accessed 17 Nov. 2024. https://repository.mouau.edu.ng/work/view/effects-of-the-ethanol-extract-of-the-leaves-of-a-muricata-on-red-blood-cell-rbc-count-ofaspirin-ulcerated-rats-nwoche-victor-u-7-2