Effects Of Hydro-Ethanolic Extract Of Amaranthus Hybrids Leaves On Some Antioxidant Enzymes In Tiboacet Amide Intoxicated Rats
ABSTRACT
The study was
carried out to evaluate the effect of hydro-alcoholic extract of Amaranthus
hybridus leaves on antioxidant enzymes of thioacetamide intoxicated rats.
Thirty-six rats used for this study were randomly distributed into six groups.
The normal control received normal feed and water, the positive control
received the thioacetamide induced water and silymarin ( conventional drug),
negative control received only thioacetamide, the test groups were treated with
100mg/kg, 200mg/kg, 400mg/kg of Amaranthus hybridus leaves extract
respectively. The administration of the thioacetamide, drug and Amaranthus
hybridus leaves extract were orally at single doses per day for nine weeks.
Result showed that the test groups significantly (p < 0.05) increased the
levels of SOD, CAT, and GPx activities when compared to the negative control.
The results suggest that thioacetamide actually induced hepatotoxicity. While
Amaranthus hybridus leaves extract appreciably increased the levels of
antioxidants in hepatic tissues.
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GODSON, G (2023). Effects Of Hydro-Ethanolic Extract Of Amaranthus Hybrids Leaves On Some Antioxidant Enzymes In Tiboacet Amide Intoxicated Rats. Mouau.afribary.org: Retrieved Nov 17, 2024, from https://repository.mouau.edu.ng/work/view/effects-of-hydro-ethanolic-extract-of-amaranthus-hybrids-leaves-on-some-antioxidant-enzymes-in-tiboacet-amide-intoxicated-rats-7-2
GODSON, GODSON. "Effects Of Hydro-Ethanolic Extract Of Amaranthus Hybrids Leaves On Some Antioxidant Enzymes In Tiboacet Amide Intoxicated Rats" Mouau.afribary.org. Mouau.afribary.org, 11 Oct. 2023, https://repository.mouau.edu.ng/work/view/effects-of-hydro-ethanolic-extract-of-amaranthus-hybrids-leaves-on-some-antioxidant-enzymes-in-tiboacet-amide-intoxicated-rats-7-2. Accessed 17 Nov. 2024.
GODSON, GODSON. "Effects Of Hydro-Ethanolic Extract Of Amaranthus Hybrids Leaves On Some Antioxidant Enzymes In Tiboacet Amide Intoxicated Rats". Mouau.afribary.org, Mouau.afribary.org, 11 Oct. 2023. Web. 17 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effects-of-hydro-ethanolic-extract-of-amaranthus-hybrids-leaves-on-some-antioxidant-enzymes-in-tiboacet-amide-intoxicated-rats-7-2 >.
GODSON, GODSON. "Effects Of Hydro-Ethanolic Extract Of Amaranthus Hybrids Leaves On Some Antioxidant Enzymes In Tiboacet Amide Intoxicated Rats" Mouau.afribary.org (2023). Accessed 17 Nov. 2024. https://repository.mouau.edu.ng/work/view/effects-of-hydro-ethanolic-extract-of-amaranthus-hybrids-leaves-on-some-antioxidant-enzymes-in-tiboacet-amide-intoxicated-rats-7-2