Effect Of The Methanol Extract Of The Leaves Of Musa Paradisiaca On The Concentration Of Glutathione (Gsh) Of Indomethacinulcerated Rats:- Akuma, Chioma Uche
ABSTRACT
Medicinal plants over the years
have attracted considerable global interest and these plants have been the
basis for medical treatments through much of human history and such plants are
still widely in use today such as the leaves of M. paradisiaca. The objectives
of this work were to examine the phytochemical constituents, acute toxicity and
lethality and the effect of the methanol extract of the leaves of M.
paradisiaca on the concentration of glutathione (GSH) of indomethacin-ulcerated
rats. The preliminary phytochemical screening revealed that the plant leaves
contained alkaloids, flavonoids, tannins, saponins, carbohydrates, reducing
sugars, proteins, steroids, terpenoids and fats and oil but resins, glycosides
and acidic compounds were not detected in the extract. The extract at the
tested doses [100, 200 and 400 mg/kg body weight (b.w)] caused significant (p
< 0.05) and dose-dependent increases in the concentrations of the GSH ofthe
rats in the test groups compared to the value obtained for the rats in the
positive control group. The effect of the extract at the dose of 400 mg/kg b.w
was comparable to that ofthe standard antiulcer drug, famotidine at the dose 50
mg/kg b.w. The result showed that the methanol extract of the leaves of M.
paradisiaca contains some bioactive constituents that ameliorate gastric ulcer,
in part, by elevating the concentration of GSH of ulcerated rats.
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-- (2023). Effect Of The Methanol Extract Of The Leaves Of Musa Paradisiaca On The Concentration Of Glutathione (Gsh) Of Indomethacinulcerated Rats:- Akuma, Chioma Uche. Mouau.afribary.org: Retrieved Nov 17, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-musa-paradisiaca-on-the-concentration-of-glutathione-gsh-of-indomethacinulcerated-rats-akuma-chioma-uche-7-2
--. "Effect Of The Methanol Extract Of The Leaves Of Musa Paradisiaca On The Concentration Of Glutathione (Gsh) Of Indomethacinulcerated Rats:- Akuma, Chioma Uche" Mouau.afribary.org. Mouau.afribary.org, 18 Oct. 2023, https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-musa-paradisiaca-on-the-concentration-of-glutathione-gsh-of-indomethacinulcerated-rats-akuma-chioma-uche-7-2. Accessed 17 Nov. 2024.
--. "Effect Of The Methanol Extract Of The Leaves Of Musa Paradisiaca On The Concentration Of Glutathione (Gsh) Of Indomethacinulcerated Rats:- Akuma, Chioma Uche". Mouau.afribary.org, Mouau.afribary.org, 18 Oct. 2023. Web. 17 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-musa-paradisiaca-on-the-concentration-of-glutathione-gsh-of-indomethacinulcerated-rats-akuma-chioma-uche-7-2 >.
--. "Effect Of The Methanol Extract Of The Leaves Of Musa Paradisiaca On The Concentration Of Glutathione (Gsh) Of Indomethacinulcerated Rats:- Akuma, Chioma Uche" Mouau.afribary.org (2023). Accessed 17 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-the-methanol-extract-of-the-leaves-of-musa-paradisiaca-on-the-concentration-of-glutathione-gsh-of-indomethacinulcerated-rats-akuma-chioma-uche-7-2