Effect Of The Ethanol Extract Of The Leaves Of Annona Muricata On Aspirin-Induced Gastric Ulcer In Rats
ABSTRACT
Over the years, many plants have been the bases for medicinal treatment and such plants are still widely in use today such as the leaves of A. muricata. The objective of this work were to determine the phytochemical constituents, acute toxicity and lethality and effects of the ethanol extract of the leaves of A. muricata on ulcer index and curative ratio. The preliminary phyto chemical screening revealed that the extract contained alkaloids, flavoniods, tannins, saponins, carbohydrates, glycosides, proteins, steroids, terpenoids and fats and oil but resins, reducing sugars and acidic compounds were not detected in the extract. The extract at the tested doses [100, 200 and 400 mg/kg body weight (b.w)] caused significant (p <0.05) and dose- dependent decreases in the ulcer indices of the rat in the test groups compared to the value obtained for the rats in the positive control group. The mean curative ratios of the extract were remarkable and dose-dependent. The effects of the extract at the dose of 400 mg/kg b.w were comparable to those of the standard anti-ulcer drug, ranitidine at the dose of 150 mg/kg b.w. In conclusion, the experimental data justify the use of leaves of A. muricata in folk medicine for the cure of gastric ulcer.
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OKORO, I (2021). Effect Of The Ethanol Extract Of The Leaves Of Annona Muricata On Aspirin-Induced Gastric Ulcer In Rats. Mouau.afribary.org: Retrieved Nov 17, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-aspirin-induced-gastric-ulcer-in-rats-7-2
IKECHUKWU, OKORO. "Effect Of The Ethanol Extract Of The Leaves Of Annona Muricata On Aspirin-Induced Gastric Ulcer In Rats" Mouau.afribary.org. Mouau.afribary.org, 25 Jun. 2021, https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-aspirin-induced-gastric-ulcer-in-rats-7-2. Accessed 17 Nov. 2024.
IKECHUKWU, OKORO. "Effect Of The Ethanol Extract Of The Leaves Of Annona Muricata On Aspirin-Induced Gastric Ulcer In Rats". Mouau.afribary.org, Mouau.afribary.org, 25 Jun. 2021. Web. 17 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-aspirin-induced-gastric-ulcer-in-rats-7-2 >.
IKECHUKWU, OKORO. "Effect Of The Ethanol Extract Of The Leaves Of Annona Muricata On Aspirin-Induced Gastric Ulcer In Rats" Mouau.afribary.org (2021). Accessed 17 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-the-ethanol-extract-of-the-leaves-of-annona-muricata-on-aspirin-induced-gastric-ulcer-in-rats-7-2