ABSTRACT
This study investigated the protective action of methanol
extract of Mucuna prurienspuriens leaves extract on alloxan-induced diabetic
rats. Analysis of superoxide dismutase (SOD), catalase, vitamin E, vitamin c,
glutathione (GSH), fasting blood sugar (FBS) and malondialdehyde (MDA) was
conducted. Twenty five (25) albino rats were distributed into five groups
consisting of five rats each. Group 1 (Normal control) received no
administration of alloxan but received normal feed and water, ad libitum
diabetes. Group 2(Negative control) was given water and feed ad libiturn
induced without treatment. Rats in Group 3 were (given water feed ad libtium
diabetes) induced and treated with glibenclamide. Group 4(given water ad libitum
and treated with 50mg/kg body weight of mucuna prurienspuriens leaves extract.
Group 5 were given feed and water, treated using 100mg/kg body weight of mucuna
prurienspuriens leaves extract. Result findings of superoxide dismutase
indicates that the 50mg of the extract showed a significant effect when
compared with the negative control and there was no significant decrease
observed in group when compared with negative and positive control. The 50mg
and 100mg of extract showed a significant decrease in catalase level at (p<0.05) when compared with the negative, normal and standard controls. The extract at 50 and 100mg showed a significant increase in GSH at (p>
IMO, E (2021). Effect Of Methanol Extract Of Mucuna Prurienspruriens Leaves On The Redox Status Of Alloxan- Induced Diabetic Rats. Mouau.afribary.org: Retrieved Nov 18, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-mucuna-prurienspruriens-leaves-on-the-redox-status-of-alloxan-induced-diabetic-rats-7-2
EZINNE, IMO. "Effect Of Methanol Extract Of Mucuna Prurienspruriens Leaves On The Redox Status Of Alloxan- Induced Diabetic Rats" Mouau.afribary.org. Mouau.afribary.org, 19 Nov. 2021, https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-mucuna-prurienspruriens-leaves-on-the-redox-status-of-alloxan-induced-diabetic-rats-7-2. Accessed 18 Nov. 2024.
EZINNE, IMO. "Effect Of Methanol Extract Of Mucuna Prurienspruriens Leaves On The Redox Status Of Alloxan- Induced Diabetic Rats". Mouau.afribary.org, Mouau.afribary.org, 19 Nov. 2021. Web. 18 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-mucuna-prurienspruriens-leaves-on-the-redox-status-of-alloxan-induced-diabetic-rats-7-2 >.
EZINNE, IMO. "Effect Of Methanol Extract Of Mucuna Prurienspruriens Leaves On The Redox Status Of Alloxan- Induced Diabetic Rats" Mouau.afribary.org (2021). Accessed 18 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-mucuna-prurienspruriens-leaves-on-the-redox-status-of-alloxan-induced-diabetic-rats-7-2