Effect Of Methanol Extract Of Citrullus Lanatus Seed On Male Hormones Profile And PSA Levels In Dihydrotestosterone/Estradiol-Valarate In Induced Benign Prostatic Hyperplasia In Male Wistar Rats:- Eke Ogechi K.
ABSTRACT
The
study investigated the acute toxicity, phytochemicals content and the effect of
methanol extract of cilrullu.s Iciiialiis on PS/\ and hormone profile level in
dihydrotestosterone estradiol-valarate induced benign prostatic hyperplasia
(BPII) in male wistar rats. The result of the phytochemical analysis showed the
presence of alkaloid, saponins, flavonoid, tannins, terpenes and reducing
sugar. The LDso was above 5000mg/kbwt. The result ofthe relative organ weight
showed no significant (P> 0.05) difference in relative kidney, lung and
heart. The relative prostate weight of the disease control increase (P<0.05)
significantly relative to the normal control while relative testes weight
decrease (P< 0.05) significantly in disease control relative to other
treatment groups. The result of the male hormone profile showed significant
(P<0.05) increase in estradiol and testosterone in disease control relative
to finasteride and methanol crude extract treated group. There was significant
(P<0.05) decrease in PSA level in extract treated groups and finasteride
(drug control) group when compared with the disease control. The result showed
marked decrease in luteinizing hormone in disease control group when compared
with other experimental groups. The result show'ed that the extract effectively
reduced the size of the enlarged prostate exogenously induced. And also
decrease the levels of PSA. It attenuated benign prostatic hyperplasia and
showed to be good prophy laxis against BPII and this might be possible because
of its phytochemical components.
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EKE, K (2023). Effect Of Methanol Extract Of Citrullus Lanatus Seed On Male Hormones Profile And PSA Levels In Dihydrotestosterone/Estradiol-Valarate In Induced Benign Prostatic Hyperplasia In Male Wistar Rats:- Eke Ogechi K.. Mouau.afribary.org: Retrieved Nov 17, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-citrullus-lanatus-seed-on-male-hormones-profile-and-psa-levels-in-dihydrotestosteroneestradiol-valarate-in-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-eke-ogechi-k-7-2
KINDNESS, EKE. "Effect Of Methanol Extract Of Citrullus Lanatus Seed On Male Hormones Profile And PSA Levels In Dihydrotestosterone/Estradiol-Valarate In Induced Benign Prostatic Hyperplasia In Male Wistar Rats:- Eke Ogechi K." Mouau.afribary.org. Mouau.afribary.org, 31 Oct. 2023, https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-citrullus-lanatus-seed-on-male-hormones-profile-and-psa-levels-in-dihydrotestosteroneestradiol-valarate-in-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-eke-ogechi-k-7-2. Accessed 17 Nov. 2024.
KINDNESS, EKE. "Effect Of Methanol Extract Of Citrullus Lanatus Seed On Male Hormones Profile And PSA Levels In Dihydrotestosterone/Estradiol-Valarate In Induced Benign Prostatic Hyperplasia In Male Wistar Rats:- Eke Ogechi K.". Mouau.afribary.org, Mouau.afribary.org, 31 Oct. 2023. Web. 17 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-citrullus-lanatus-seed-on-male-hormones-profile-and-psa-levels-in-dihydrotestosteroneestradiol-valarate-in-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-eke-ogechi-k-7-2 >.
KINDNESS, EKE. "Effect Of Methanol Extract Of Citrullus Lanatus Seed On Male Hormones Profile And PSA Levels In Dihydrotestosterone/Estradiol-Valarate In Induced Benign Prostatic Hyperplasia In Male Wistar Rats:- Eke Ogechi K." Mouau.afribary.org (2023). Accessed 17 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-methanol-extract-of-citrullus-lanatus-seed-on-male-hormones-profile-and-psa-levels-in-dihydrotestosteroneestradiol-valarate-in-induced-benign-prostatic-hyperplasia-in-male-wistar-rats-eke-ogechi-k-7-2