Effect Of Hydro-Ethanolic Extract Of Amaranthus Hybridus Leaves On Some Hematological Profile Of Thioacetamide Intoxicated Rats:- Ebeh Gabriel C.
ABSTRACT
The study was carried out to evaluate the
effect of hydro-ethanolic extract of Amaranthus hybridus leaves on some
hematological profile of thioacetamide intoxicated rats (wistar). Thirty-six
animals of male gender were used and divided into six groups, each group
consisting of six animals. The normal control received normal feed and water,
the positive control received the thioacetamide induced water and silymarin
(conventional drug), negative control received only thioacetamide, the test
groups were treated with lOOmg/kg, 200mg/kg, 400mg/kg body weight of Amaranthus
hybridus leaves extract respectively. The administration of the thioacetamide,
drug and Amaranthus hybridus leaves extract were orally at single doses per day
for nine weeks. The result of the test groups significantly (p < 0.05)
increased the hematological levels of PCV, HB, RBC, and WBC when compared to
the Negative control groups after nine weeks ofAmaranthus hybridus
administration to each rat. The results suggest that thioacetamide induces
hepatotoxicity, while Amaranthus hybridus leaves extract appreciably increases
the levels ofhematological parameters in the blood.
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EBEH, C (2024). Effect Of Hydro-Ethanolic Extract Of Amaranthus Hybridus Leaves On Some Hematological Profile Of Thioacetamide Intoxicated Rats:- Ebeh Gabriel C.. Mouau.afribary.org: Retrieved Nov 17, 2024, from https://repository.mouau.edu.ng/work/view/effect-of-hydro-ethanolic-extract-of-amaranthus-hybridus-leaves-on-some-hematological-profile-of-thioacetamide-intoxicated-rats-ebeh-gabriel-c-7-2
CHUKWUEMEKA, EBEH. "Effect Of Hydro-Ethanolic Extract Of Amaranthus Hybridus Leaves On Some Hematological Profile Of Thioacetamide Intoxicated Rats:- Ebeh Gabriel C." Mouau.afribary.org. Mouau.afribary.org, 25 Mar. 2024, https://repository.mouau.edu.ng/work/view/effect-of-hydro-ethanolic-extract-of-amaranthus-hybridus-leaves-on-some-hematological-profile-of-thioacetamide-intoxicated-rats-ebeh-gabriel-c-7-2. Accessed 17 Nov. 2024.
CHUKWUEMEKA, EBEH. "Effect Of Hydro-Ethanolic Extract Of Amaranthus Hybridus Leaves On Some Hematological Profile Of Thioacetamide Intoxicated Rats:- Ebeh Gabriel C.". Mouau.afribary.org, Mouau.afribary.org, 25 Mar. 2024. Web. 17 Nov. 2024. < https://repository.mouau.edu.ng/work/view/effect-of-hydro-ethanolic-extract-of-amaranthus-hybridus-leaves-on-some-hematological-profile-of-thioacetamide-intoxicated-rats-ebeh-gabriel-c-7-2 >.
CHUKWUEMEKA, EBEH. "Effect Of Hydro-Ethanolic Extract Of Amaranthus Hybridus Leaves On Some Hematological Profile Of Thioacetamide Intoxicated Rats:- Ebeh Gabriel C." Mouau.afribary.org (2024). Accessed 17 Nov. 2024. https://repository.mouau.edu.ng/work/view/effect-of-hydro-ethanolic-extract-of-amaranthus-hybridus-leaves-on-some-hematological-profile-of-thioacetamide-intoxicated-rats-ebeh-gabriel-c-7-2