Assessment Of Alpha Amylase And Pancreatic Lipase Inhibitory Potential Of Hyptis Suaveolensand Mode Of Inhibition:- Lawai, Lukman
ABSTRACT
Diabetes, a state of improperly regulated
homeostasis of carbohydrate and lipid metabolism is one of the major killers in
recent times. Most prevalent form of diabetes is non insulin dependent diabetes
mellitus (NIDDM or type II). Rapid hydrolysis of starch mediated pancreatic
alpha amylase and lipase followed by glucose uptake at intestine results in
sudden rise in blood glucose levels, causing hyperglycemia in type II diabetic
patients. The purpose of this present study is to investigate the effect of
Hyptis suaveolens on alpha amylase and pancreatic lipase and their mode of
inhibition. The results showed that the plant extract (20 mg/mL; 51.8%) was
able to inhibit alpha amylase comparable to the standard acarbose at 12.5pg/mL
(78) in a competitive manner. Also the plant extract showed a promising
pancreatic lipase inhibitory effect with increasing concentrations similar to
acarbose in an uncompetitive manner as mode of inhibition. Hyptis suaveolens
could be used in the management of diabetic complications
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LAWAL, L (2023). Assessment Of Alpha Amylase And Pancreatic Lipase Inhibitory Potential Of Hyptis Suaveolensand Mode Of Inhibition:- Lawai, Lukman. Mouau.afribary.org: Retrieved Nov 17, 2024, from https://repository.mouau.edu.ng/work/view/assessment-of-alpha-amylase-and-pancreatic-lipase-inhibitory-potential-of-hyptis-suaveolensand-mode-of-inhibition-lawai-lukman-7-2
LUKMAN, LAWAL. "Assessment Of Alpha Amylase And Pancreatic Lipase Inhibitory Potential Of Hyptis Suaveolensand Mode Of Inhibition:- Lawai, Lukman" Mouau.afribary.org. Mouau.afribary.org, 18 Oct. 2023, https://repository.mouau.edu.ng/work/view/assessment-of-alpha-amylase-and-pancreatic-lipase-inhibitory-potential-of-hyptis-suaveolensand-mode-of-inhibition-lawai-lukman-7-2. Accessed 17 Nov. 2024.
LUKMAN, LAWAL. "Assessment Of Alpha Amylase And Pancreatic Lipase Inhibitory Potential Of Hyptis Suaveolensand Mode Of Inhibition:- Lawai, Lukman". Mouau.afribary.org, Mouau.afribary.org, 18 Oct. 2023. Web. 17 Nov. 2024. < https://repository.mouau.edu.ng/work/view/assessment-of-alpha-amylase-and-pancreatic-lipase-inhibitory-potential-of-hyptis-suaveolensand-mode-of-inhibition-lawai-lukman-7-2 >.
LUKMAN, LAWAL. "Assessment Of Alpha Amylase And Pancreatic Lipase Inhibitory Potential Of Hyptis Suaveolensand Mode Of Inhibition:- Lawai, Lukman" Mouau.afribary.org (2023). Accessed 17 Nov. 2024. https://repository.mouau.edu.ng/work/view/assessment-of-alpha-amylase-and-pancreatic-lipase-inhibitory-potential-of-hyptis-suaveolensand-mode-of-inhibition-lawai-lukman-7-2