Abstract
The barks and leaves of Khaya senegalensis were
screened for antimicrobial activity. Plant components were extracted using
methanol and water. The methanol and the water extracts of - the barks and
leaves were tested against Escherichia coli, Staphylococcus aureus, Salmonella
enterica typhi, Pseudomonas aeruginosa, S. aureus. (ATCC 25923), Escherichia
coli ( ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Enterococcu faecalis
(ATCC 7080), using diffusion method and results compared with standard
antibiotics discs of Gentamycin and Ceftriaxone. The methanolic bark extract
showed activity against E. coli at low concentration of 500g/ml with diameter
zone of inhibition of 15±0mm. The same extract showed activity against S.
aureus, P. aeruginosa and E. faecalis at concentration of 2000µg/ml showing the
zone of inhibition of 15.5±0.07mm, 9.5±0.7mm and 16±0mm, respectively. The
leaves water extract showed weak activity against the organisms. The leaves
water extract was active at concentration of 2000µg/ml. Higher concentrations
of >2000µg/ml, were required to produce bactericidal activity on the test
organisms. Phytochemical screening showed that tannins, alkaloids, saponnis,
flavanoids and phenols were active compounds present in the methanolic bark and
leaves extract of Khaya senegalensis. The leaves water extracts showed that
tannins, alkaloids, saponnis and phenols were present but had no flavanoids.
That may be the reason for its weak activity against test organisms. Methanolic
bark and leaves extracts had highest inhibitory activity on the test organisms
probably because they contain more compounds than the water, bark and leaves
extracts. Bark and leaves extract of Khaya senegalensis may be useful for the
treatment of some diseases whose causative agents are susceptible to its
in-vitro antibacterial activity.
NNABUKO, N (2023). Antimicrobial And Phytochemical Screening Of Khaya Senegalensis.. Mouau.afribary.org: Retrieved Nov 13, 2024, from https://repository.mouau.edu.ng/work/view/antimicrobial-and-phytochemical-screening-of-khaya-senegalensis-7-2
NNABUKO, NNABUKO. "Antimicrobial And Phytochemical Screening Of Khaya Senegalensis." Mouau.afribary.org. Mouau.afribary.org, 09 Feb. 2023, https://repository.mouau.edu.ng/work/view/antimicrobial-and-phytochemical-screening-of-khaya-senegalensis-7-2. Accessed 13 Nov. 2024.
NNABUKO, NNABUKO. "Antimicrobial And Phytochemical Screening Of Khaya Senegalensis.". Mouau.afribary.org, Mouau.afribary.org, 09 Feb. 2023. Web. 13 Nov. 2024. < https://repository.mouau.edu.ng/work/view/antimicrobial-and-phytochemical-screening-of-khaya-senegalensis-7-2 >.
NNABUKO, NNABUKO. "Antimicrobial And Phytochemical Screening Of Khaya Senegalensis." Mouau.afribary.org (2023). Accessed 13 Nov. 2024. https://repository.mouau.edu.ng/work/view/antimicrobial-and-phytochemical-screening-of-khaya-senegalensis-7-2