ABSTRACT
The objective of this study was to screen some
commonly used antibiotics contained in antibiotic discs made by different
manufacturers (both local and foreign) for their efficacy against some clinical
bacterial isolates. Samples of urine, HVS and wound swab were collected from
Federal Medical Center Umuahia. The organisms isolated were pure cultures of
Staphylococcus aureus, Esherichia coli and Pseudomonas aeruginosa. The disc
susceptibility test was used to screen the antibiotics used which includes
augumentin, erythromycin, gentamicin and ciprofloxacin. It was observed that
ciproflox showed the highest activity against all the organisms used. The zones
of inhibition were 59mm and 31mm (for local and foreign discs respectively)
against Staphylococcus aureus, 44mm and 28mm (local and foreign discs) against
Escherichia coli and 48 and 18mm (local and foreign discs) against Pseudomonas
aeruginosa. Augumentin showed the least activity and was effective only against
Staphylococcus aureus with zone of inhibition of 27mm and Pseudomonas
aeruginosa 37mm (for local discs) but resistant to the foreign discs against
the same organisms. Augumentin was not effective against E. coli for both local
and foreign antibiotics. Pseudomonas showed the least susceptibility when
compared with other organisms, showing the least zones of inhibition against
the same antibiotics used. The study revealed that the antibiotic contained in
locally made discs appear to be more effective, showing higher zones of
inhibition when compared to foreign discs. However, the difference in the zones
of inhibition of gentamicin, erythromycin, augumentin and ciproflox contained
in locally produced commercial antibiotic discs as against ones contained in
antibiotic discs produced commercially by a foreign company were statistically
significant (p<0.05). In as much as this study has demonstrated that foreign
discs appear to be less effective against agents of infection, the local discs
with highest activities are hereby recommended in therapy.
-- (2023). Antimicrobial Activities Of Commonly Used Antibiotics , On Selected Pathogenic Bacteria. Mouau.afribary.org: Retrieved Nov 24, 2024, from https://repository.mouau.edu.ng/work/view/antimicrobial-activities-of-commonly-used-antibiotics-on-selected-pathogenic-bacteria-7-2
--. "Antimicrobial Activities Of Commonly Used Antibiotics , On Selected Pathogenic Bacteria" Mouau.afribary.org. Mouau.afribary.org, 09 Feb. 2023, https://repository.mouau.edu.ng/work/view/antimicrobial-activities-of-commonly-used-antibiotics-on-selected-pathogenic-bacteria-7-2. Accessed 24 Nov. 2024.
--. "Antimicrobial Activities Of Commonly Used Antibiotics , On Selected Pathogenic Bacteria". Mouau.afribary.org, Mouau.afribary.org, 09 Feb. 2023. Web. 24 Nov. 2024. < https://repository.mouau.edu.ng/work/view/antimicrobial-activities-of-commonly-used-antibiotics-on-selected-pathogenic-bacteria-7-2 >.
--. "Antimicrobial Activities Of Commonly Used Antibiotics , On Selected Pathogenic Bacteria" Mouau.afribary.org (2023). Accessed 24 Nov. 2024. https://repository.mouau.edu.ng/work/view/antimicrobial-activities-of-commonly-used-antibiotics-on-selected-pathogenic-bacteria-7-2