Antidiabetic Potential Of Methanol Bulb Extracts Of Bulbine Natalensis And Leaf Extract Of Eucomis Autumnalis Carbohydrate Metabolizing Enzymes And Pancreatic Lipase Inhibition.
ABSTRACT
Diabetes mellitus is a metabolic disorder of glucose metabolism. The management of blood glucose level is the hallmark in the treatment of this disease. This may be achieved through the use of oral hypoglycemic drugs such as sulfonylureas, metformin, insulin secretagogues, and alpha amylase, alpha glucosidase and pancreatic lipase inhibitors. The purpose of the present study was to investigate the inhibitory effect of methanol bulb extract of Bulbine natalensis and leaf extract of Eucomis autur'ialis on the activities of alpha amylase, alpha glucosidase and pancreatic lipase. This was performed using porcine pancreatic alpha amylasc from Aspergillus oryzae, alpha glucosidase from Saccharomyces cerevisiae and pancreatic lipase. Highest concentration of methanol bulb extract of B. natalensis and leaf extract of E. autumnal is possesses the highest percentage inhibitory activity against arnylase (B.N lmg/ml (70.15±2.14%), E.A lmg/ml (71.19±0.85%), alpha glucosidase (B.N 0.2mg/ml (73.24±1.05%), E.A 0.2mg/mi (62.11±0.18%) and pancreatic lipase (B.N lrng/ml (49.69±2.37%), E.A lmg/rnl (38.44±2.86%) comparable to the standard drugs, acarbose (80.34±0.18%) and orlistat (60.22+1.68%). Kinetic analysis revealed that the methanol extract of both plants inhibited the alpha amylase uncompetitive but displayed mixed noncompctiti\'e mode of inhibition towards alpha glucosidase and pancreatic lipase. It can he concluded that methanol extracts of B. natalensis bulb and E. autumnalis leaves exhibited a potent inhibitory activity on the three enzymes studied.
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-- (2021). Antidiabetic Potential Of Methanol Bulb Extracts Of Bulbine Natalensis And Leaf Extract Of Eucomis Autumnalis Carbohydrate Metabolizing Enzymes And Pancreatic Lipase Inhibition.. Mouau.afribary.org: Retrieved Nov 17, 2024, from https://repository.mouau.edu.ng/work/view/antidiabetic-potential-of-methanol-bulb-extracts-of-bulbine-natalensis-and-leaf-extract-of-eucomis-autumnalis-carbohydrate-metabolizing-enzymes-and-pancreatic-lipase-inhibition-7-2
--. "Antidiabetic Potential Of Methanol Bulb Extracts Of Bulbine Natalensis And Leaf Extract Of Eucomis Autumnalis Carbohydrate Metabolizing Enzymes And Pancreatic Lipase Inhibition." Mouau.afribary.org. Mouau.afribary.org, 16 Jun. 2021, https://repository.mouau.edu.ng/work/view/antidiabetic-potential-of-methanol-bulb-extracts-of-bulbine-natalensis-and-leaf-extract-of-eucomis-autumnalis-carbohydrate-metabolizing-enzymes-and-pancreatic-lipase-inhibition-7-2. Accessed 17 Nov. 2024.
--. "Antidiabetic Potential Of Methanol Bulb Extracts Of Bulbine Natalensis And Leaf Extract Of Eucomis Autumnalis Carbohydrate Metabolizing Enzymes And Pancreatic Lipase Inhibition.". Mouau.afribary.org, Mouau.afribary.org, 16 Jun. 2021. Web. 17 Nov. 2024. < https://repository.mouau.edu.ng/work/view/antidiabetic-potential-of-methanol-bulb-extracts-of-bulbine-natalensis-and-leaf-extract-of-eucomis-autumnalis-carbohydrate-metabolizing-enzymes-and-pancreatic-lipase-inhibition-7-2 >.
--. "Antidiabetic Potential Of Methanol Bulb Extracts Of Bulbine Natalensis And Leaf Extract Of Eucomis Autumnalis Carbohydrate Metabolizing Enzymes And Pancreatic Lipase Inhibition." Mouau.afribary.org (2021). Accessed 17 Nov. 2024. https://repository.mouau.edu.ng/work/view/antidiabetic-potential-of-methanol-bulb-extracts-of-bulbine-natalensis-and-leaf-extract-of-eucomis-autumnalis-carbohydrate-metabolizing-enzymes-and-pancreatic-lipase-inhibition-7-2