ABSTRACT

This study investigated the antibiotic susceptibility pattern of Pseudomonas aeruginosa isolated from clinical specimens, from in-patient, out-patient and intensive care unit of Abia State specialist hospital. Clinical specimens which include wound, urine, sputum, were analyzed for Pseudomonas aeruginosa. Forty eight isolates of Pseudomonas aeruginosa were isolated using  standard bacteriological procedure. The isolated pathogen showed resistance to Ciprofloxacin (33.33%), Streptomycin (83.33%), and showed susceptibility to Levoflaxocin (87.50%), Ceftriaxone (81.25%) Gentamycin (79.16%). From the result obtained, Pseudomonas aeruginosa isolates from in-patient and out patient, intensive care unit of Abia state specialist hospital were highly susceptible to Levofloxacin (87.50%) and Gentamycin (79.16%) than other antibiotics. Hence, the use of antibiotics should be monitored among the group to avoid further drug resistance.

TABLE OF CONTENT

Title page i

Cover page ii

Certification iii

Dedication iv

Acknowledgement v

Abstract vi

Table of content vii

List of table viii

CHAPTER ONE

 INTRODUCTION

1.0 Background of the Study 1

1.1 Statement of Problem 3 

1.2 Significance of Study 4 

1.3    Limitations of the Study 4 

CHAPTER TWO

2.1 Literature Review 7

2.2 Clinical Manifestation 8

2.3 Antibiotic Resistance 11

2.4 Theoretical Framework 13   

2.5 Current Therapeutic Options 14 

CHAPTER THREE 

METHODOLOGY

3.0 Materials and Method 20

3.1 Setting 20

3.2 Specimen Collection and Processing 20

3.3 Media Preparation 22

3.4 Biochemical Test 22

3.5 Susceptibility Test 24

CHAPTER FOUR

4.0 Result 25

4.1 Patients and Specimen Data 25

CHAPTER FIVE

5.1 Discussion 30

5.2 Conclusion and Recommendation 31

REFERENCES 32

LIST OF TABLE

Table 4.1: Age and Sex Distribution of Patients Infected with 

Pseudomonas aeruginosa 26

Table 4.2: Distribution of Specimens from where Pseudomonas 

aeruginosa was Isolated 27

Table 4.3: Bacterial isolated from patients in various wards 28

Table 4.4: Antibiotic Susceptibility Pattern of Pseudomonas

 aeruginosa from Clinical Specimens. 29