ABSTRACT 

The antibiotic sensitivity pattern of Echerichia  coli isolated from faecal samples from healthy domestic livestock ( goats, local fowls and broilers)   was determined. Inoculation was carried out using the streaking method of inoculation and he sensitive was determined using the Disc diffusion method .50 E.coli strains were isolated from the three locations. In location 1 16(35.7%) were resistance to Ampicillin, 10(35.7%) to Gentamycin and 1(3.6%) to Ciprofloxacin. In location 2, 6(50.0%) were resistant to Ampicillin, 5(41.7%) to Gentamycin and streptomycin, while all the isolates were susceptible to Ciprofloxacin. In location 3, 6(60.0%) showed resistance to Ampicillin, while there is no evidence of resistant against Oxytetracyclin and ciprofloxacin 0(0.00%). Comparing Resistance rates according to all spruces of samples, 10(66.7%) of Goat isolates were resistance to Ampicillin, 7(46.7%) to Gentamycin and streptomycin respectively, 19(76.0%) from Local fowl isolates showed resistance to Ampicillin while the least percentage was recorded against ciprofloxacin 2(8.00%). From the broilers isolates 5(50.0%) were resistant to Ampicillin and Gentamycin and there was no evidence of resistance recorded against ciprofloxacin. The use of antibiotics in this feeding of these animals should be checked so as to reduce the development of drug resistance.

TABLE OF CONTENTS 

Title page i

Certification             ii

Dedication iii

Acknowledgment iv

Table of content v

List of Tables             vi 

Abstract vii

CHAPTER ONE

INTRODUCTION

1.1   Introduction              1

1.2   Aims and Objectives              2

CHAPTER TWO

 LITERATURE REVIEW 3

2.1   Classification of Escherichia Coli             4

2.2  Morphology and Identification of Escherichia Coli                         4

2.3 classification of  Echerichia coli                         5

2.4  Escherichia Coli Strains             5

2.5  Antigens             6

2.6  Epidemiology             6

2.7  Antibiotic Resistance of Escherichia Coli             7

CHAPTER THREE

MATERIALS AND METHODS

3.1 Material Used            10

3.2 Sample Collection            10

3.3 Preparation of Media            10

3.4 Sample Cultivation            11

3.5 Characterization and Identification of Bacterial Isolates                       11

   3.5.2   Gram Staining            12

3.5.2   Indole Test            12

3.5.3   Catalase Test            12

3.5.4   Citrate Test            13

3.5.5   Oxidase Test            13

3.6     Antibiotic Susceptibility Test            14

CHAPTER FOUR

Results           15 

CHAPTER FIVE

 Discussion            20

5.1 Conclusion            21

 5.2 Recommendation                                                                                               21

    References