ABSTRACT

Three of the isolates were from three different wound samples (60%) identified as A, B nod ( one isolate was pie (20%) and autotimer was fioum ear infection (20%). The isolates were tested with eight antibiotics, which include Ofloxacin, Gentanicin, Augmentin, Anioxycill in, Nitrofurantoin, N alidixic acid, Cotrimoxazole aid Tetracycline to find their resistance patterns. The antibiotic sensitivity test was performed three times and an average was obtained. The isolate from wound C sample and the urine sample showed a 62.5% asistance to all antibiotics, the wound B sample showed a 3 7.5% resistance, the wound A sample showed a 25.0% resistance while the ear sample sl1owed a 12.5% resistance. All [lie isolates were sensitive to Ofloxacin while Tetracycline had the highest resistance rate of 80%, followed by Nalidixic acid, (60%) resistance. Anioxycillin, Augmnentin, Cotrimoxazole amid Nitrofurantoin had 40% resistance rate each while Geimtamicin had the lowest resistance rate of 20%. The pattern of resistance among the isolates of P. aeruginosa calls for more antimicrobial surveillance in order to check the emergence of resistant strains of these bacteria. susceptible to opportunistic infections. In this group of patients, I'. aeruginosa is responsible for pneumonia and septicemia with attributable deaths reaching 30% (Fergie ci al, 1994; Bergen and Slielliamer, 1996). P.aeruginosa is also one of the most common and lethal pathogens responsible for ventilator-associated pneumonia in intubated patients (Dunn and Wunderinek, 1995), with directly attributable deaths rates reaching 38% (Brewer ci a!, 1996). In burn patients, P. aeruginosa, bacteremia has declined as a result of better wound treatment and dietary changes (removal of raw vegetables, which can be contaminated with P.aeruginosa, from time diet) (Kluytmans, 1997). However, P.aeruginosa outbreaks in burn units are still associated with high (60%) death rates (Richard ci a!, 1994). In the expanding AiDS population, P. aeruginosa bacteremias is associated with 50% of deaths (Mendelson ci a!, 1994). Because of the widespread use of antibiotics especially in developing countries, the resistance profile of microorganisms is changing, as evidenced by the increasing occurrence of antibiotic resistance among bacterial populations (Farral; 1985; Ako-Nai eta!, 1995; O'Brieii 1986). Pseudoinonas aeruginosa is a ubiquitous organism fi-equently isolated from clinical specimens. Because these organisms are usually inherently resistant to many antimicrobial agents, treatment of Pseudoinonal infections is difficult, and mortality as usually high. (Liu ci a/,1992; Pollack, 1990; Zak,1980).