ABSTRACT

The aim of the study was assessing the antibacterial effect of Methanol and Aqueous extracts of ginger and non-antibiotic drugs against Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, Enterococcus faecalis. The antibacterial activities of extracts were evaluated using the disk diffusion method as well as agar well diffusion method; the inhibitory zones were recorded in millimeters. The minimal inhibitory concentration (MIC) of the plant extracts against E. coli, S. aureus and P. aeruginosa, E. fecaelis and S. typhi were assessed using microdilution method. The synergistic effect between plants and extraction of antibiotics and / or Non-antibiotic drugs was assessed using disk diffusion method. The results of this study showed that methanolic extracts used against E. coli, S. aureus and P. aeruginosa E. fecaelis and S. typhi were showed antimicrobial and synergistic effect with most antibiotics better than methanolic and aquatic extracts. The results of this study showed that there is a decrease in MIC in case of methanolic extract of E. faecalis against S. typhi and the methanol and aquatic extract of ginger against S. aureus varying from 6.25 to 3.125 mg/ml, and the methanol extract of E. faecalis against P. areuginosa (6.25 mg/ml).the phytochemical results shows alkaloid 1.92, Saponin 1.08, Terpenoid 2.28 and Flavonoid 0.56.  Thereby, our results indicate the possibility of using these extracts in the treatment of bacterial infections, and the results of this study was encouraging, despite the need for clinical studies to determine of the real effectiveness and potential toxic effects in vivo. These results was revealed the importance of plant extracts when associated with antibiotic and Non-antibiotic drugs in control of bacteria.