Anti-Diabetic Screening Potential Of Methanol Extracts From Aichornea Laxflora (Pax And Hoffman) And Dialium Guineense (Willd) Against Carbohydrate Hydrolyzing Enzymes And Pancreatic Lipase.
ABSTRACT
Diabetes mellitus is a metabolic disorder .of glucose metabolism. The management of blood glucose level is the hallmark in the treatment of this disease. This may be achieved through the use of oral hypoglycemic drugs such as sulfonylureas, metformin, insulin secretagogues, and alpha amylase, alpha glucosidase and pancreatic lipase inhibitors. The purpose of the present study was to investigate Anti-diabetic Screening potential of methanol extract from Aichornea lax ?flora and Dialium guineense against carbohydrate hydrolyzing enzymes such as alpha amylase, alpha glucosidase and pancreatic lipase. This was performed using porcine pancreatic alpha amylase from Aspergillus oryzae, alpha glucosidase from Saccharomyces cerevisiae and pancreatic lipase. Highest concentration of methanol extract of A. laxflora and extract of D.guineense possesses the highest percentage inhibitory activity against amylase (A.laxflora 1mg/mi (60.87%± 0.724) , D.guineense lmg/ml (77.34% ±11.33); alpha glucosidase (A.laxflora 0.2mg/mi (78.44% ± 0.29), D.guineense 0.2mg/mi (66.5 5%±0.34)and pancreatic lipase (A.1a41ora lmg/ml (52.33%± 1.64), D.guineense lmg/ml (54.73%±5.66)comparable to the standard drugs, acarbose (80.00% ±0.73) and orlistat (60.03±1.35). It can be concluded that methanol extracts of A.laxflora and D.guineense exhibited a potent inhibitory activity on the three enzymes studied.
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ABONYI, S (2021). Anti-Diabetic Screening Potential Of Methanol Extracts From Aichornea Laxflora (Pax And Hoffman) And Dialium Guineense (Willd) Against Carbohydrate Hydrolyzing Enzymes And Pancreatic Lipase.. Mouau.afribary.org: Retrieved Nov 17, 2024, from https://repository.mouau.edu.ng/work/view/anti-diabetic-screening-potential-of-methanol-extracts-from-aichornea-laxflora-pax-and-hoffman-and-dialium-guineense-willd-against-carbohydrate-hydrolyzing-enzymes-and-pancreatic-lipase-7-2
SONIA, ABONYI. "Anti-Diabetic Screening Potential Of Methanol Extracts From Aichornea Laxflora (Pax And Hoffman) And Dialium Guineense (Willd) Against Carbohydrate Hydrolyzing Enzymes And Pancreatic Lipase." Mouau.afribary.org. Mouau.afribary.org, 25 Jun. 2021, https://repository.mouau.edu.ng/work/view/anti-diabetic-screening-potential-of-methanol-extracts-from-aichornea-laxflora-pax-and-hoffman-and-dialium-guineense-willd-against-carbohydrate-hydrolyzing-enzymes-and-pancreatic-lipase-7-2. Accessed 17 Nov. 2024.
SONIA, ABONYI. "Anti-Diabetic Screening Potential Of Methanol Extracts From Aichornea Laxflora (Pax And Hoffman) And Dialium Guineense (Willd) Against Carbohydrate Hydrolyzing Enzymes And Pancreatic Lipase.". Mouau.afribary.org, Mouau.afribary.org, 25 Jun. 2021. Web. 17 Nov. 2024. < https://repository.mouau.edu.ng/work/view/anti-diabetic-screening-potential-of-methanol-extracts-from-aichornea-laxflora-pax-and-hoffman-and-dialium-guineense-willd-against-carbohydrate-hydrolyzing-enzymes-and-pancreatic-lipase-7-2 >.
SONIA, ABONYI. "Anti-Diabetic Screening Potential Of Methanol Extracts From Aichornea Laxflora (Pax And Hoffman) And Dialium Guineense (Willd) Against Carbohydrate Hydrolyzing Enzymes And Pancreatic Lipase." Mouau.afribary.org (2021). Accessed 17 Nov. 2024. https://repository.mouau.edu.ng/work/view/anti-diabetic-screening-potential-of-methanol-extracts-from-aichornea-laxflora-pax-and-hoffman-and-dialium-guineense-willd-against-carbohydrate-hydrolyzing-enzymes-and-pancreatic-lipase-7-2