Acute Toxicity Value And Effects On Hematological Parameters Of Different Solvent Extract Of Dacryodes Edulis Against Monosodium Glutamate Induced Toxicity In Wister Rats:- Ebeleagu Joseph C

EBELEAGU JOSEPH CHIDIEBERE | 56 pages (9393 words) | Projects

ABSTRACT

 Hematological indices are usually used in the prognosis and possibly identification of onset of disease conditions. Medicinal plants have been used for the management of ailments but at high doses, some plants could deplete health status and at times lethal thus warranting this study aimed at acute toxicity value and effects on hematological parameters of different solvent extract of Dacryodesedulis against monosodium glutamate induced toxicity in Wister rats. Total of 48 rats were shared into 8 groups of 6 animals each. Group 1 received food and water while group 2 received 800mg/kg monosodium glutamate. Group 3 was co-treated sylimarin. The other treatment groups were treated with ethanol fraction, methanol fraction, ethylacetete fraction, Nhexane fraction and aqueous fraction. The result ofthe two phases of acute toxicity done (lOmg, lOOmg and 1000 for phase 1) and (1600mg, 2900mg and 5000mg for phase 2) showed no death of animals across all fractions even at the highest dose. The result of hematological indices showed reduced RBC, Hb, PCV with increased WBC in the MSG group suggesting toxicity. However, the RBC, Hb, PCV were increased while the WBC was decreased across the groups co-treated different fractions of D. edulis. Hence, it could be concluded that the different fractions of D.edulis were not toxic to the rats rather, improved the hematological indices from the toxicity induced by high dose ofmonosodium glutamate.

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APA

EBELEAGU, C (2024). Acute Toxicity Value And Effects On Hematological Parameters Of Different Solvent Extract Of Dacryodes Edulis Against Monosodium Glutamate Induced Toxicity In Wister Rats:- Ebeleagu Joseph C. Mouau.afribary.org: Retrieved Nov 21, 2024, from https://repository.mouau.edu.ng/work/view/acute-toxicity-value-and-effects-on-hematological-parameters-of-different-solvent-extract-of-dacryodes-edulis-against-monosodium-glutamate-induced-toxicity-in-wister-rats-ebeleagu-joseph-c-7-2

MLA 8th

CHIDIEBERE, EBELEAGU. "Acute Toxicity Value And Effects On Hematological Parameters Of Different Solvent Extract Of Dacryodes Edulis Against Monosodium Glutamate Induced Toxicity In Wister Rats:- Ebeleagu Joseph C" Mouau.afribary.org. Mouau.afribary.org, 24 Oct. 2024, https://repository.mouau.edu.ng/work/view/acute-toxicity-value-and-effects-on-hematological-parameters-of-different-solvent-extract-of-dacryodes-edulis-against-monosodium-glutamate-induced-toxicity-in-wister-rats-ebeleagu-joseph-c-7-2. Accessed 21 Nov. 2024.

MLA7

CHIDIEBERE, EBELEAGU. "Acute Toxicity Value And Effects On Hematological Parameters Of Different Solvent Extract Of Dacryodes Edulis Against Monosodium Glutamate Induced Toxicity In Wister Rats:- Ebeleagu Joseph C". Mouau.afribary.org, Mouau.afribary.org, 24 Oct. 2024. Web. 21 Nov. 2024. < https://repository.mouau.edu.ng/work/view/acute-toxicity-value-and-effects-on-hematological-parameters-of-different-solvent-extract-of-dacryodes-edulis-against-monosodium-glutamate-induced-toxicity-in-wister-rats-ebeleagu-joseph-c-7-2 >.

Chicago

CHIDIEBERE, EBELEAGU. "Acute Toxicity Value And Effects On Hematological Parameters Of Different Solvent Extract Of Dacryodes Edulis Against Monosodium Glutamate Induced Toxicity In Wister Rats:- Ebeleagu Joseph C" Mouau.afribary.org (2024). Accessed 21 Nov. 2024. https://repository.mouau.edu.ng/work/view/acute-toxicity-value-and-effects-on-hematological-parameters-of-different-solvent-extract-of-dacryodes-edulis-against-monosodium-glutamate-induced-toxicity-in-wister-rats-ebeleagu-joseph-c-7-2

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