Trypanocidal Effect Of Extracts Of Chanca Piedra (Phyllanthus Amarus) In Trypanosoma Bruce! Infection Of Albino Rats
ABSTRACT
Aqueous and ethanol extracts of Phyllanihus
arnarus (Schum and Thonn) were tested for trypanocidal activity agaiiist
Trypanosoma brucel in albino rats. The rats were divided into six groups of
four rats per group. Three groups were inoculated intraperitoneally with T.
brucei and two groups out of the three were treated daily with 40mg/kg body
weight with the aqueous and ethanol extracts respectively, while the third
group had no treatment. The three other groups served as treatment control. The
parasitaernia and packed cell volume of the rats were recorded at start of the
experiment and subsequently at 4 days interval. There was no significant
difference (P < 0.05) observed between the mean distributions of parasitaernia
in the untreated control group when compared with the treated groups. There was
a drop in the mean packed cell volume of the infected rats from day 4 to day 28
post infection but the mean packed cell volume of the non-infected groups
remained fairly constant. It was concluded that Phyllanthus amarus has no
trypanocidal activity and also no effect on the PCV of the albino rats.
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EZECHUKWU, S (2021). Trypanocidal Effect Of Extracts Of Chanca Piedra (Phyllanthus Amarus) In Trypanosoma Bruce! Infection Of Albino Rats. Mouau.afribary.org: Retrieved Oct 18, 2024, from https://repository.mouau.edu.ng/work/view/trypanocidal-effect-of-extracts-of-chanca-piedra-phyllanthus-amarus-in-trypanosoma-bruce-infection-of-albino-rats-7-2
S., EZECHUKWU. "Trypanocidal Effect Of Extracts Of Chanca Piedra (Phyllanthus Amarus) In Trypanosoma Bruce! Infection Of Albino Rats" Mouau.afribary.org. Mouau.afribary.org, 13 Jul. 2021, https://repository.mouau.edu.ng/work/view/trypanocidal-effect-of-extracts-of-chanca-piedra-phyllanthus-amarus-in-trypanosoma-bruce-infection-of-albino-rats-7-2. Accessed 18 Oct. 2024.
S., EZECHUKWU. "Trypanocidal Effect Of Extracts Of Chanca Piedra (Phyllanthus Amarus) In Trypanosoma Bruce! Infection Of Albino Rats". Mouau.afribary.org, Mouau.afribary.org, 13 Jul. 2021. Web. 18 Oct. 2024. < https://repository.mouau.edu.ng/work/view/trypanocidal-effect-of-extracts-of-chanca-piedra-phyllanthus-amarus-in-trypanosoma-bruce-infection-of-albino-rats-7-2 >.
S., EZECHUKWU. "Trypanocidal Effect Of Extracts Of Chanca Piedra (Phyllanthus Amarus) In Trypanosoma Bruce! Infection Of Albino Rats" Mouau.afribary.org (2021). Accessed 18 Oct. 2024. https://repository.mouau.edu.ng/work/view/trypanocidal-effect-of-extracts-of-chanca-piedra-phyllanthus-amarus-in-trypanosoma-bruce-infection-of-albino-rats-7-2