Waste water from fish production system is increasingly being used for arable crop production particularly in areas with shortage of water supply with some benefits and also some risks on the environment and man. This work on “The Effects of Irrigating with Waste Water (WW) and Borehole Water (BW) from Fish Culture on Soil Characteristics and Growth of fluted pumpkin (Telfairia occidentalis)” was carried out in the Fish Farm of Michael Okpara University of Agriculture, Umudike. Three water regimes namely WWED, WW2D and WWID and a Control were used as treatment. The experiment was conducted on prepared beds using a Randomized Complete Block Design (RCBD) with three (3) replications which was carried out from January to February, 2017. Genetically uniform seeds of (T. occidentalis) extracted from one pod obtained from the National Root Crops Research Institute, Umudike were used for the experiment. The seeds were planted one per hole into the beds at spacing of 0.2m. Measurements were done on the fresh weight of T. occidentalis leaves. The levels of selected minerals in both T. occidentalis leaves and soils, and also concentration of selected heavy metals were determined. The physio-chemical properties of both BW and WW were determined prior to the commencement of trial and compared with the WHO/FAO standards.  The pH value of BW was 7.14 while the waste water was 8.24 indicating that both were within WHO/FAO standard of 6.5-8.5. TDS (mg/l) for the BW and WW were 20.60 and 204.00 respectively. The TSS (mg/l) for BW and WW were 11.00 and 248 respectively. TSS and TDS for WW were elevated when compared to WHO/FAO TSS standard (30mg/l) and TDS (100mg/l). The mineral contents of the WW from the fish pond were significantly higher than that of BW. Calcium (Ca) in WW was 152.84 mg/l which was four times higher than that of BW;  K was 336.46mg/l in WW which was 45 times more than BW; Na in WW was 136.46 mg/l and is more than 4 times higher than that of BW; and N in WW was 8.10% which is 35 times more than that of BW. WHO/FAO standards for Ca, Mg, K, P and N were 200mg/l, 150mg/l, 200mg/l, 200mg/l and 10mg/l respectively. Results for the heavy metal concentration in irrigation water showed that all heavy metals analyzed for were not detectable in the BW except for Fe (0.04mg/l). In WW, the concentrations (mg/l) of Cd, Cr, Pb, Fe, and Cu were 0.245, 0.086, 0.427, 0.882 and 0.284 respectively while the WHO/FAO acceptable standards for them are 0.01mg/l, 0.05mg/l, 0.05mg/l, 0.30mg/l, and 1.0mg/l respectively. There were significant differences amongst treatment plots irrigated with WW at different levels (WWED, WW2D and WWID) and the control plot (BWED). WWED had the highest fresh shoot yield with a weight of 24.85kg, followed by WW2D – 22.00kg, WW1D – 18.17kg and the least was BWED which weighed 14.17kg. Using waste water from fish pond provided improved yield but caution needs to be exercised to avoid heavy metal contamination.