Synthesis, Characterization And Antibacterial Activities Of Phenylmethylidene-(1-3-THIAZOLE-2YLMETHYL) Sulfonyl Methylaniline Schiff Base and its Fe (III) Ni (II) and Mn (II) Complexes.
ABSTRACT
Phenylmethylidene-(1-3-thiazole-2ylmethyl)
sulfonylmethylaniline Schiff bases [PTSA] was prepared by a reaction between
benzaldehyde and sulphathiazole. Fe(III), Mn(II) and Ni(II) complexes of PTSA
were also synthesized, melting point and conductivity of the ligand and metal
complexes were determined. The PTSA and Fe(III), Mn(II) and Ni(II) complexes
were characterized by Ultraviolet/Visible, IR, HNMR and 13CNMR
spectroscopy. Low conductivity value ranging from 10.5-17.2 Sm2.mol-1
indicated
the non-electrolytic nature of the PTSA and Fe(III), Mn(II) and Ni(II)
complexes. The melting point of the PTSA and its complexes ranges from 244 -
286 The PTSA behaved as a tridentate ligand towards Mn, Fe and Ni ion, it
complexed at -NH group and two C=N group. It has the general formular of
[M(PTSA)n] (where M = metal ion, n = number of moles of ligand). A trigonal
geometry has been proposed for the metal complexes. PTSA and metal (II)
complexes have been screened for their in
vitro antibacterial activity against four bacterial strains staphylococcus aureus, Escherichia coli,
Pseudomonas aeruginosa, Salmonella
typhi. It was observed that the complexes were more potent than PTSA
against the bacterial strains used. In line with the findings, PTSA metal
complexes of Fe(III), Mn(II) and Ni(II) may be used as metal based drugs in the
treatment of bacterial infections caused by staphylococcus
aureus, Escherichia coli, Pseudomonas aeruginosa,
Salmonella typhi.
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ANYANWU, A (2022). Synthesis, Characterization And Antibacterial Activities Of Phenylmethylidene-(1-3-THIAZOLE-2YLMETHYL) Sulfonyl Methylaniline Schiff Base and its Fe (III) Ni (II) and Mn (II) Complexes.. Mouau.afribary.org: Retrieved Nov 17, 2024, from https://repository.mouau.edu.ng/work/view/synthesis-characterization-and-antibacterial-activities-of-phenylmethylidene-1-3-thiazole-2ylmethyl-sulfonyl-methylaniline-schiff-base-and-its-fe-iii-ni-ii-and-mn-ii-complexes-7-2
ANYANWU, ANYANWU. "Synthesis, Characterization And Antibacterial Activities Of Phenylmethylidene-(1-3-THIAZOLE-2YLMETHYL) Sulfonyl Methylaniline Schiff Base and its Fe (III) Ni (II) and Mn (II) Complexes." Mouau.afribary.org. Mouau.afribary.org, 17 Oct. 2022, https://repository.mouau.edu.ng/work/view/synthesis-characterization-and-antibacterial-activities-of-phenylmethylidene-1-3-thiazole-2ylmethyl-sulfonyl-methylaniline-schiff-base-and-its-fe-iii-ni-ii-and-mn-ii-complexes-7-2. Accessed 17 Nov. 2024.
ANYANWU, ANYANWU. "Synthesis, Characterization And Antibacterial Activities Of Phenylmethylidene-(1-3-THIAZOLE-2YLMETHYL) Sulfonyl Methylaniline Schiff Base and its Fe (III) Ni (II) and Mn (II) Complexes.". Mouau.afribary.org, Mouau.afribary.org, 17 Oct. 2022. Web. 17 Nov. 2024. < https://repository.mouau.edu.ng/work/view/synthesis-characterization-and-antibacterial-activities-of-phenylmethylidene-1-3-thiazole-2ylmethyl-sulfonyl-methylaniline-schiff-base-and-its-fe-iii-ni-ii-and-mn-ii-complexes-7-2 >.
ANYANWU, ANYANWU. "Synthesis, Characterization And Antibacterial Activities Of Phenylmethylidene-(1-3-THIAZOLE-2YLMETHYL) Sulfonyl Methylaniline Schiff Base and its Fe (III) Ni (II) and Mn (II) Complexes." Mouau.afribary.org (2022). Accessed 17 Nov. 2024. https://repository.mouau.edu.ng/work/view/synthesis-characterization-and-antibacterial-activities-of-phenylmethylidene-1-3-thiazole-2ylmethyl-sulfonyl-methylaniline-schiff-base-and-its-fe-iii-ni-ii-and-mn-ii-complexes-7-2