ABSTRACT
Diabetes
mellitus (DM) is a metabolic disorder characterized by a loss of glucose
homeostasis, due to disturbance of carbohydrate, fats, and protein metabolism,
resulting from defects in insulin production and action or both. In Nigeria,
the number of people suffering from diabetes mellitus is rapidly increasing.
There are several oral hypoglycemic drugs used in the treatment of DM but are
not devoid of adverse effect. However, natural products from plant source have
proven to be effective and safe in the treatment of OM. An ethnobotanical
survey conducted in Imo state (Isiala Mbano & Owerri) and Abia state
(Ikwuano) in South Eastern Nigeria revealed nine medicinal plants frequently
mentioned by the traditional healers in the treatment of diabetes mellitus.
Nine medicinal plants namely; Chlorophora excelsa (root), Strophanthus
hispisdus (root), Picralima nitida (seed), Persea americana (seed), Loranthus
micranthus (leaf), Ceiba pentandra (leaf), Synsepa/um dolficicum (leaf),
Anthocleista djalonensis (leaf) and Anacardium occidentale (leaf). The
phytochemical properties of these plants were estimated using standard TLC
method while the antioxidant activities were done using 1,
l-diphenyl-2-picrylhydrazl (DPPH), 2, 2'-azino-bis-3- ethylbenzothiazoline-6-sulfonic-acid
(ABTS), and Ferric Reducing Antioxidant Power (FRAP).Some of the samples had
(Ceiba pentandra and Anacadium occidenta/e) a robust antioxidant potential
while some of the samples exhibited moderate antioxidant potential. The thin
layer Chromatography (TLC) profiling revealed the presence of phenolics,
flavonoids, alkaloids, saponins with yellow-brown coloured zones at daylight
indicating the presence of alkaloid, yellow coloured zone indicating the
presence of flavonoids, and blue coloured zone indicating the presence of
phenols. The presence of these compounds in the plantsindicates the presence of
phytochemical in the plant extracts in support of their antioxidant and
biological activity. The a-amylase inhibition test indicated that some of the
plant extracts (Chlorophora excelsa, Picralima nitida, Synsepalum dolficicum,
Anacardium occidentale) showed good a-amylase inhibitory effect and can act as
good anti-diabetic agents and therefore at least supports their use in the
treatment of Diabetes mellitus. The antioxidant activities seen in these plants
need to be further explored in synergy with the possible antidiabetic
properties of the plants in the treatment of OM.
OHANYEREM, O (2024). Alpha amylase inhibitory activities and antioxidative properties of some medicinal plants used in the South East, Nigeria:-Ohanyerem, Princemartins E.. Mouau.afribary.org: Retrieved Sep 08, 2024, from https://repository.mouau.edu.ng/work/view/alpha-amylase-inhibitory-activities-and-antioxidative-properties-of-some-medicinal-plants-used-in-the-south-east-nigeria-ohanyerem-princemartins-e-7-2
OHANYEREM, OHANYEREM. "Alpha amylase inhibitory activities and antioxidative properties of some medicinal plants used in the South East, Nigeria:-Ohanyerem, Princemartins E." Mouau.afribary.org. Mouau.afribary.org, 26 Feb. 2024, https://repository.mouau.edu.ng/work/view/alpha-amylase-inhibitory-activities-and-antioxidative-properties-of-some-medicinal-plants-used-in-the-south-east-nigeria-ohanyerem-princemartins-e-7-2. Accessed 08 Sep. 2024.
OHANYEREM, OHANYEREM. "Alpha amylase inhibitory activities and antioxidative properties of some medicinal plants used in the South East, Nigeria:-Ohanyerem, Princemartins E.". Mouau.afribary.org, Mouau.afribary.org, 26 Feb. 2024. Web. 08 Sep. 2024. < https://repository.mouau.edu.ng/work/view/alpha-amylase-inhibitory-activities-and-antioxidative-properties-of-some-medicinal-plants-used-in-the-south-east-nigeria-ohanyerem-princemartins-e-7-2 >.
OHANYEREM, OHANYEREM. "Alpha amylase inhibitory activities and antioxidative properties of some medicinal plants used in the South East, Nigeria:-Ohanyerem, Princemartins E." Mouau.afribary.org (2024). Accessed 08 Sep. 2024. https://repository.mouau.edu.ng/work/view/alpha-amylase-inhibitory-activities-and-antioxidative-properties-of-some-medicinal-plants-used-in-the-south-east-nigeria-ohanyerem-princemartins-e-7-2